术前臭氧关节注射联合胫骨高位截骨术对膝骨关节炎患者术后功能恢复与炎症调控的影响

doi:10.3969/j.issn.1006-5725.2026.08.008

Abstract

Abstract:

Objective To observe the effects of preoperative ozone injection combined with high tibial osteotomy （HTO） on joint function， gait recovery， and serum inflammatory factors in patients with knee osteoarthritis （KOA）. Methods A total of 93 patients with KOA who underwent HTO in the hospital were retrospectively enrolled from March 2024 to March 2025. Based on the presence or absence of preoperative knee injection of ozone， they were divided into group A （injection， n = 47） and group B （non-injection， n = 46）. The changes in joint function， including the Western Ontario and McMaster Universities Osteoarthritis Index （WOMAC）， Hospital for Special Surgery Knee Score （HSS score）， medial proximal tibial angle （MPTA）， and range of motion （ROM）， gait recovery （step length， walking speed， stride frequency）， and serum levels of Interleukin （IL）-1β， IL-6， IL-8， and IL-10 before and after treatment were compared between the two groups. Knee pain， as measured by the visual analogue scale （VAS）， was observed at 5 weeks， 1 month， and 6 months after surgery， and complications were recorded. Results At 5 weeks post-surgery， the WOMAC and MPTA in group A were lower than those in group B， whereas the HSS score and ROM were higher than those in group B （P < 0.05）. In the 120-meter gait test， the step length， walking speed， and stride frequency in group A were all higher than those in group B （P < 0.05）. The serum levels of IL-1β， IL-6， and IL-8 in group A were lower than those in group B， and the level of IL-10 was higher than that in group B （P < 0.05）. At 5 weeks， 1 month， and 6 months post-surgery， the Visual Analog Scale （VAS） scores in group A were lower than those in group B （P < 0.05）. There was no significant difference in the incidence of postoperative complications between the two groups （P > 0.05）. Conclusion Intra-knee injection of ozone can effectively promote the postoperative recovery of joint function and gait， alleviate the serum inflammatory response， and relieve postoperative pain in patients with KAO before HTO.

Key words: knee osteoarthritis, high tibial osteotomy, knee injection of ozone, joint function, gait, inflammatory response, pain

CLC Number:

R684.3

Xiaosong LI,Jinjin YIN,Kaihong GUI,Wei XUE,Junlai SONG. Effect of preoperative ozone joint injection combined with high tibial osteotomy on postoperative functional recovery and inflammatory regulation in patients with knee osteoarthritis[J]. The Journal of Practical Medicine, 2026, 42(8): 1361-1366.

Figures/Tables 6

Tab.1

Comparison of baseline data between the two groups"

特征	A组（n = 47）	B组（n = 46）	t/χ²值	P值
性别（男/女）	24/23	19/27	0.891	0.345
年龄（ $x ˉ ? ± ? s$ ）/岁	65.48 ± 2.85	64.39 ± 3.13	1.757	0.082
病程（ $x ˉ ? ± ? s$ ）/年	4.87 ± 1.25	4.59 ± 1.36	1.034	0.304
Kellgren-Lawrence分级（Ⅲ/Ⅳ级）/例	20/27	22/24	0.261	0.609

Tab.1

Tab.2

Tab.3

Tab.4

Tab.5

Tab.6

References 29

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组别	WOMAC/分		HSS评分/分		MPTA/°		ROM/°
组别	术前	术后5周	术前	术后5周	术前	术后5周	术前	术后5周
A组（n = 47）	65.58 ± 5.89	34.43 ± 2.31^*	56.47 ± 3.96	81.96 ± 2.14^*	91.58 ± 1.24	88.26 ± 0.95^*	134.25 ± 2.34	141.63 ± 1.25^*
B组（n = 46）	64.97 ± 6.12	41.52 ± 3.69^*	56.88 ± 2.87	77.45 ± 1.97^*	91.81 ± 1.11	90.21 ± 0.87^*	135.11 ± 3.59	138.54 ± 1.13^*
t值	0.490	11.132	0.571	10.544	0.942	10.327	1.371	12.497
P值	0.625	< 0.001	0.570	< 0.001	0.349	< 0.001	0.174	< 0.001

组别	步长/cm		步速/（cm/s）		步频/（步/min）
组别	术前	术后5周	术前	术后5周	术前	术后5周
A组（n = 47）	32.58 ± 4.56	60.28 ± 3.87^*	80.35 ± 5.25	98.52 ± 2.69^*	84.69 ± 2.41	105.24 ± 2.13^*
B组（n = 46）	32.96 ± 5.13	56.31 ± 4.34^*	79.83 ± 5.14	94.35 ± 3.36^*	85.12 ± 1.69	101.31 ± 1.47^*
t值	0.378	4.658	0.483	6.614	0.994	10.334
P值	0.706	< 0.001	0.631	< 0.001	0.323	< 0.001

组别	IL-1β/（pg/mL）		IL-6/（pg/mL）		IL-8/（mg/L）		IL-10/（pg/mL）
组别	术前	术后5周	术前	术后5周	术前	术后5周	术前	术后5周
A组（n = 47）	22.52 ± 6.98	13.25 ± 5.12^*	211.45 ± 52.36	82.21 ± 25.36^*	20.36 ± 2.69	7.58 ± 1.16^*	15.23 ± 3.12	28.65 ± 4.21^*
B组（n = 46）	21.84 ± 7.56	16.17 ± 6.11^*	209.58 ± 47.41	98.63 ± 24.58^*	20.87 ± 3.16	8.36 ± 1.52^*	14.89 ± 3.05	22.34 ± 3.87^*
t值	0.451	2.500	0.180	3.170	0.839	2.786	0.531	7.521
P值	0.653	0.014	0.857	0.002	0.404	0.007	0.597	< 0.001

组别	VAS
组别	术前	术后5周	术后1个月	术后6个月
A组（n = 47）	6.11 ± 0.85	4.25 ± 0.26^*#	2.76 ± 0.51^*#	1.46 ± 0.25^*#
B组（n = 46）	6.09 ± 0.78	4.89 ± 0.14^*	3.87 ± 0.58^*	2.18 ± 0.19^*

组别	关节粘连	下肢深静脉血栓	切口感染	总并发症发生
A组（n = 47）	1（2.13）	2（4.26）	1（2.13）	4（8.51）
B组（n = 46）	1（2.17）	3（6.52）	3（6.52）	7（15.22）
χ²值				1.003
P值				0.317

Effect of preoperative ozone joint injection combined with high tibial osteotomy on postoperative functional recovery and inflammatory regulation in patients with knee osteoarthritis

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