静脉输注利多卡因治疗类风湿关节炎疼痛的机制与临床前景

doi:10.3969/j.issn.1006-5725.2026.03.001

Abstract

Abstract:

Rheumatoid Arthritis （RA） is an autoimmune disease， with pain being its primary symptom. The mechanisms underlying RA pain involve both inflammatory and neuropathic components. Lidocaine， a classic amido-type local anesthetic， has gained widespread application in treating inflammatory and neuropathic pain due to its analgesic， anti-inflammatory， and immunomodulatory properties when administered intravenously. Given the exact match between the pathogenesis of RA pain and the pharmacological actions of intravenous lidocaine， this review explores the therapeutic potential of intravenous lidocaine infusion for RA pain. It aims to offer new insights into the clinical application of intravenous lidocaine for managing RA-related pain.

Key words: rheumatoid arthritis, lidocaine, intravenous, inflammation, neuropathic pain

CLC Number:

R593.2

Ting WU,Mingzhong XIA,Xiangdi YU. Mechanisms and clinical prospects of intravenous lidocaine for pain management in rheumatoid arthritis[J]. The Journal of Practical Medicine, 2026, 42(3): 355-362.

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Mechanisms and clinical prospects of intravenous lidocaine for pain management in rheumatoid arthritis

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