首发精神分裂症男性患者吸烟状况与其认知功能及人格特征的关系

doi:10.3969/j.issn.1006-5725.2025.12.022

Abstract

Abstract:

Objective To explore the associations among smoking behavior， cognitive function， and personality traits in first-episode male patients with schizophrenia， thereby providing theoretical underpinnings for individualized treatment strategies in clinical settings. Methods A total of 140 first-episode male inpatients with schizophrenia admitted to the hospital from January 2022 to December 2023 were recruited. According to their smoking behavior， they were categorized into a smoking group （n = 80） and a non-smoking group （n = 60）. Moreover， healthy controls were recruited and classified into a healthy smoking group （n = 62） and a healthy non-smoking group （n = 67） based on their smoking status. The Positive and Negative Syndrome Scale （PANSS） was employed to evaluate psychiatric symptoms in the schizophrenia groups. Nicotine dependence was measured using the Fagerstr?m Test for Nicotine Dependence （FTND） in the two smoking groups. Cognitive function and personality traits were assessed in all participants using the Repeatable Battery for the Assessment of Neuropsychological Status （RBANS） and the Eysenck Personality Questionnaire （EPQ）， respectively. Results Regarding cognitive function， the smoking group among schizophrenia patients demonstrated significantly higher scores than the non-smoking group in immediate memory， attention， and delayed memory （all P < 0.05）. Among schizophrenia patients， FTND scores were moderately negatively correlated with attention and delayed memory （r = -0.552 and -0.657 respectively； both P < 0.001）. Concerning personality traits， smokers had significantly higher scores in neuroticism and psychoticism compared to non-smokers （both P < 0.001）. Both patient groups had significantly lower lie scale scores when contrasted with healthy controls （P < 0.01）， while the healthy smoking group showed significantly higher extraversion scores than the other groups. Conclusions The smoking behavior of male patients during their first episode of schizophrenia exhibits specific characteristics in relation to cognitive performance and personality traits. Smokers demonstrate relatively superior performance in cognitive domains including attention， immediate memory， and delayed memory. However， higher degrees of nicotine dependence are associated with poorer cognitive function， especially in the aspects of attention and delayed memory. Regarding personality， smoking patients display elevated levels of neuroticism and psychoticism. These findings indicate that smoking behavior may be closely associated with cognitive functioning and personality traits， thus meriting clinical attention in the management of schizophrenia.

Key words: first-episode schizophrenia, male, smoking, cognitive function, personality characteristics

CLC Number:

R749.3

Cong LIU,Fei ZHAI,Min LI,Xiaoli ZHANG,Han SHI,Ningning GUO,Changhong WANG. Association between smoking status， cognitive function， and personality traits in first⁃episode male patients with schizophrenia[J]. The Journal of Practical Medicine, 2025, 41(12): 1922-1928.

Figures/Tables 5

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References 44

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组别	例数	年龄/岁	受教育程度/年	婚姻状况（已婚/未婚）/例
SP吸烟组	80	35.2 ± 6.8	11.5 ± 2.3	30/50
SP非吸烟组	60	34.8 ± 7.2	11.2 ± 2.1	22/38
健康吸烟组	62	33.5 ± 6.5	12.0 ± 2.0	28/34
健康非吸烟组	67	34.0 ± 6.3	11.8 ± 1.9	32/35
F/χ2值		1.305	1.239	2.524
P值		0.273	0.296	0.471

组别	例数	病程/月	阳性症状	阴性症状	一般精神病理症状	总分
SP吸烟组	80	7.1 ± 2.3	18.4 ± 2.4	17.7 ± 2.3	18.2 ± 3.1	54.3 ± 4.8
SP非吸烟组	60	6.9 ± 2.1	17.8 ± 2.7	18.1 ± 2.6	19.0 ± 3.7	54.8 ± 5.6
t值		0.535	1.364	-0.946	-1.356	-0.555
P值		0.593	0.175	0.346	0.178	0.580

组别	例数	即刻记忆	视觉广度	语言功能	注意力	延迟记忆
SP吸烟组	80	95.75 ± 15.02	91.55 ± 13.82	91.10 ± 13.57	97.74 ± 10.46	84.62 ± 11.18
SP非吸烟组	60	88.95 ± 14.43	91.93 ± 11.74	87.78 ± 14.44	90.33 ± 10.41	81.62 ± 11.22
健康吸烟组	62	100.00 ± 12.77	97.66 ± 11.66	98.10 ± 12.64	102.73 ± 11.17	90.87 ± 11.16
健康非吸烟组	67	101.75 ± 11.17	102.09 ± 12.06	100.76 ± 11.12	102.46 ± 11.99	96.45 ± 10.75
F值		13.07	16.55	9.92	19.64	21.15
P值		< 0.001	< 0.001	< 0.001	< 0.001	< 0.001

项目	即刻记忆	视觉广度	语言功能	注意力	延迟记忆
SP吸烟组 r值	-0.285	-0.213	-0.139	-0.552	-0.657
SP吸烟组 P值	0.0103	0.0583	0.2204	< 0.001	< 0.001
健康吸烟组 r值	-0.263	0.131	0.203	-0.063	-0.137
健康吸烟组 P值	0.0385	0.3094	0.1130	0.6273	0.2882

组别	例数	精神质	内外向	神经质	掩饰性
SP吸烟组	80	7.62 ± 2.81	13.78 ± 3.88	16.70 ± 4.09	10.62 ± 3.27
SP非吸烟组	60	7.55 ± 2.61	13.43 ± 4.49	15.90 ± 3.75	11.72 ± 3.37
健康吸烟组	62	5.95 ± 2.26	15.82 ± 4.43	10.32 ± 3.48	13.47 ± 3.41
健康非吸烟组	67	5.19 ± 1.99	14.51 ± 3.71	8.15 ± 4.32	14.33 ± 3.23
F值		16.35	4.20	77.55	18.21
P值		< 0.001	0.006	< 0.001	< 0.001

Association between smoking status， cognitive function， and personality traits in first⁃episode male patients with schizophrenia

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