The Journal of Practical Medicine ›› 2021, Vol. 37 ›› Issue (20): 2670-2674.doi: 10.3969/j.issn.1006⁃5725.2021.20.020

• Medical Examination and Clinical Diagnosis • Previous Articles     Next Articles

Respective and joint values of mycobacterium tuberculosis⁃specific cellular immunity test and tuberculosis antibody test in diagnosis of male genital system tuberculosis

ZHANG Chunlei*，DING Haoshuai，KANG Yafen，MENG Dongdong，XU Dongbo，YANG Qi，ZHOU Fenghai，CHANG Dehui.    

  1. Department of Urology， No.940 Hospital of Joint Logistics Support Force of Chinese PLA，Lanzhou 730050，China
  • Online:2021-10-25 Published:2021-10-25
  • Contact: CHANG Dehui E⁃mail：chdhui@126.com；ZHOU Fenghai E⁃mail：zhoufengh@163.com

Abstract:

Objective To evaluate the repective and joint values of mycobacterium tuberculosis ⁃specific cellular immunity test and tuberculosis antibody test in diagnosis of tuberculosis in male reproductive system. Methods A total of 174 cases of tuberculosis and inflammation in male reproductive system who were treated in our hospital from January 2017 to June 2020 were retrospectively analyzed to evaluate the diagnostic values of the two tests in assisting the diagnosis of tuberculosis in male reproductive system. The cases were divided into four groups with four test methods respectively（method A：mycobacterium tuberculosis⁃specific cellular immunity test， method B：tuberculosis antibody test，method C：serial test，method D：parallel test）. Results The consistency of the two tests was poor（kappa = 0.022），and the difference in diagnosis results was statistically significant（χ2 = 31.7，P < 0.001）. The sensitivity of method A（81.6%）and method D（84.2%）was sigificanlty higher than that of method B（21.1%，χ2 = 19.4，P < 0.01）and method C（18.4%，χ2 = 22.0，P < 0.01）. The specificity of method B（93.9%）and method C（100.0%）was higher than that of method A（59.2%，χ2 = 11.1，P < 0.01）and method D（57.1%，χ2 = 18.1，P < 0.01）. Se，PPV，and LR+ were at their highest level and α was at the lowest in the method C group. Sp，NPV，Youden index were at their highest level，while β and LR⁃ were at their lowest in the method D group. The AUC areas of methods A to D were 0.704，0.575，0.592，and 0.686，respectively. Conclusion When the two test methods are positive at the same time ，the possibility of reproductive system tuberculosis is the greatest，and the misdiagnosis rate is the lowest. When the two test methods are negative at the same time，the possibility of reproductive system tuberculosis is the least，and the missed diagnosis rate is the lowest. When tested alone，the tuberculosis specific cellular immune test has a higher diagnostic efficiency than the tuberculosis antibody test. When combined，the parallel diagnostic efficiency is higher than the serial diagnostic efficiency.

Key words: