Abstract:

Objective To investigate the distribution， risk factors and prognosis of VA-ECMO patients with capillary leakage syndrome （CLS ）. Methods 115 cases of VA-ECMO were collected in Emergency department， ICU 1 and 2 of Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine from December 2019 to December 2023 for prospective clinical observation study. It was observed the operation time and status of VA-ECMO and whether VA-ECMO patients were complicated with CLS. At the same time， type of disease， blood gas pH， HCO₃^- concentration， lactate value （LAC）， serum albumin and so on were recorded. The influence of various factors on VA-ECMO with CLS was analyzed by binary Logistic regression. T test was used for measurement data and χ ² test was used for counting data. Results Capillary leakage syndrome in VA-ECMO patients were 61 cases， which had accounted for 53.04%. Sepsis， ECPR， pH value and LAC were the risk factors for VA-ECMO with CLS （P < 0.05）. The operation failure rate of ECMO in 24 hours of CLS group was 49.18% higher than that of non-CLS group （P < 0.001）. The mean running time of ECMO in CLS group was 39.53 hours， which was lower than that of non-CLS group （t = 2.318，P < 0.05）. The mortality rate of CLS group was 88.24%， higher than that of non-CLS group （57.69%） （χ ² = 14.18，P < 0.001）. Conclusions The proportion of VA-ECMO combined with CLS was not low. Sepsis， ECPR， pH value and LAC were risk factors for VA-ECMO with CLS， and VA-ECMO combined with CLS seriously affected the operation of ECMO. For patients with VA-ECMO， it should be paid more attention to observe whether they have capillary leakage and its risk factors， and the potential etiology should be treated early to promote the progress of ECMO and improve their prognosis.

Key words: VA-ECMO, capillary leakage syndrome, ECPR, sepsis