中性粒细胞/淋巴细胞比率和单核/高密度脂蛋白胆固醇比率在突发性耳聋患者中的表达水平及与预后的相关性

doi:10.3969/j.issn.1006-5725.2024.24.011

Abstract

Abstract:

Objective To explore the correlation between neutrophil/lymphocyte ratio （NLR） and monocyte/high density lipoprotein cholesterol ratio （MHR） and the onset and prognosis of sudden deafness （SSNHL）. Methods 138 patients with sudden deafness who were treated in the hospital from January 2022 to May 2024 were selected as the study group， and 116 normal healthy people were selected as the control group. The changes of NLR and MHR in two groups and different types of SSNHL patients were compared. Logistic regression was used to explore the prognostic factors of patients with SSNHL. Results NLR and MHR in the study group were significantly higher than those in the control group （P < 0.05）. There were statistical differences in the average hearing threshold， total cholesterol （TC）， fibrinogen （FIB）， platelet count （PLT）， cortisol （COR）， NLR and MHR in patients with different types of SSNHL （P < 0.05）. NLR， MHR and SSNHL were significantly correlated （P < 0.05）. The increase of NLR and MHR is a risk factor for poor prognosis in patients with SSNHL. Conclusion NLR and MHR are closely related to the pathogenesis of SSNHL and are important factors leading to poor prognosis of patients with SSNHL.

Key words: neutrophil/lymphocyte ratio, monocyte/high density lipoprotein cholesterol ratio, sudden deafness, prognosis, correlation analysis

CLC Number:

R764

Hongmei ZHU,Yongjiu HUANG,Jiusheng CHU,Xiuhong. PANG. Expression level of neutrophil/lymphocyte ratio and monocyte/high density lipoprotein cholesterol ratio in patients with sudden deafness and their correlation with prognosis[J]. The Journal of Practical Medicine, 2024, 40(24): 3503-3508.

Figures/Tables 4

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References 27

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组别	例数	NLR	MHR
研究组	138	2.18 ± 0.36	0.34 ± 0.08
对照组	116	1.04 ± 0.32	0.22 ± 0.04
t值		18.693	10.380
P值		< 0.001	< 0.001

指标	低频下降型（n = 58）	中高频下降型（n = 48）	平坦型（n = 22）	全聋型（n = 10）	F/χ ² 值	P值
年龄/岁	51.10 ± 3.02	51.30 ± 3.15	52.29 ± 3.53	54.31 ± 3.82	1.67	0.182
性别/例					7.735	0.052
男	20	18	16	8
女	38	30	6	2
病变部位/［例（%）］					4.311	0.695
左侧	22（37.93）	16（33.33）	10（45.45）	4（40.00）
右侧	26（44.83）	18（37.50）	12（54.55）	4（40.00）
双侧	10（17.24）	14（29.17）	0（0.00）	2（20.00）
是否伴随耳鸣、眩晕/［例（%）］					1.069	0.785
是	36（62.07）	30（62.50）	10（45.45）	6（60.00）
否	22（37.93）	18（37.50）	12（54.55）	4（40.00）
平均听阈/dB	45.94 ± 1.24	48.22 ± 1.79^?	51.10 ± 2.53^?△	54.14 ± 2.86^?△	42.31	< 0.001
SBP/mmHg	122.44 ± 11.41	124.20 ± 11.49	125.02 ± 11.52	125.49 ± 11.58	0.22	0.881
DBP/mmHg	78.65 ± 6.77	80.01 ± 6.58	83.54 ± 6.79	85.13 ± 7.10	2.30	0.085
TC/（mmol/L）	4.53 ± 0.15	5.21 ± 0.57^?	6.02 ± 1.20^?△	6.55 ± 1.76^?△	18.23	< 0.001
FIB/（g/L）	2.79 ± 0.20	3.17 ± 0.37^?	6.39 ± 0.59^?△	7.14 ± 0.76^?△#	363.26	< 0.001
PLT/（×10⁹/L）	203.31 ± 51.44	210.65 ± 51.23	246.31 ± 51.96^?	258.79 ± 52.37^?	3.09	0.0331
COR/（nmol/L）	314.73 ± 27.40	341.13 ± 35.89^?	381.54 ± 49.67^?△	395.62 ± 58.74^?△	5.51	0.003
IL-6/（pg/mL）	60.30 ± 5.30	64.58 ± 8.76^?	67.52 ± 5.14^?	68.44 ± 5.28^?	2.45	0.072
TNF-α/（pg/L）	81.01 ± 6.73	81.26 ± 6.29	85.04 ± 6.58	85.63 ± 6.71	1.64	0.189
NLR/%	1.53 ± 0.33	2.43 ± 0.46^?	2.94 ± 0.58^?△	3.10 ± 0.69^?△	40.00	< 0.001
MHR/%	0.25 ± 0.03	0.30 ± 0.05^?	0.53 ± 0.09^?△	0.64 ± 0.10^?△#	119.17	< 0.001

指标	恢复良好组（n = 92）	恢复不佳组（n = 46）	t/χ ² 值	P值
年龄/岁	51.43 ± 3.56	51.91 ± 3.64	0.524	0.602
性别/例			1.455	0.228
男	38	24
女	54	22
病变部位/［例（%）］	-	-	1.189	0.5522
左侧	36（39.13）	16（34.78）
右侧	42（45.65）	19（39.13）
双侧	14（15.22）	12（26.07）
临床分型/［例（%）］			7.219	0.065
低频下降型	46（50.00）	12（26.09）
高频下降型	30（32.61）	18（39.13）
平坦型	14（15.22）	8（17.39）
全聋型	2（2.17）	8（17.39）
是否伴随耳鸣、眩晕/［例（%）］			13.945	< 0.001
是	48（52.17）	34（73.91）
否	44（47.83）	12（26.09）
平均听阈/dB	46.95 ± 1.30	50.55 ± 2.79	7.337	< 0.001
SBP/mmHg	123.46 ± 11.35	124.13 ± 11.40	0.231	0.818
DBP/mmHg	80.10 ± 6.72	80.92 ± 6.58	0.481	0.632
TC/（mmol/L）	5.07 ± 0.35	5.34 ± 0.21	3.399	0.001
FIB/（g/L）	3.54 ± 0.57	4.35 ± 0.76	4.966	< 0.001
PLT/（×10⁹/L）	206.36 ± 51.46	237.49 ± 47.94	2.422	0.018
COR/（nmol/L）	325.70 ± 32.64	369.88 ± 50.98	4.368	< 0.001
IL-6/（pg/mL）	62.14 ± 5.87	64.53 ± 5.62	1.617	0.111
TNF-α/（pg/L）	81.33 ± 6.14	83.57 ± 6.10	1.432	0.157
NLR/%	2.05 ± 0.35	2.42 ± 0.21	4.658	< 0.001
MHR/%	0.32 ± 0.08	0.37 ± 0.09	2.347	0.022

变量	回归系数	标准误	Wald χ²	P值
FIB	2.674	0.828	10.419	0.001
NLR	5.659	1.594	12.605	< 0.001
MHR	17.480	6.382	7.503	0.006
平均听阈	0.978	0.590	2.742	0.098
是否伴随耳鸣、眩晕	0.042	0.029	2.012	0.156
TC	0.145	0.181	0.643	0.423
PLT	0.006	0.006	1.119	0.290
COR	0.005	0.010	0.216	0.642

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Expression level of neutrophil/lymphocyte ratio and monocyte/high density lipoprotein cholesterol ratio in patients with sudden deafness and their correlation with prognosis

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