急性轻度创伤性脑损伤与记忆障碍相关默认模式网络分析

doi:10.3969/j.issn.1006-5725.2024.10.014

Abstract

Abstract:

Objective To observe the changes of memory function in patients with mild traumatic brain injury （mTBI）， and to explore the correlation between functional connection （FC） changes and montreal cognitive assessment （MoCA） scale scores in the mTBI cohort. Methods Thirty?nine patients with acute mTBI and 39 healthy controls were prospectively collected. All subjects underwent rs?fMRI scans， and FC values were calculated in both groups. Results Compared with healthy controls， the FC of the left posterior cingulate cortex， the left cuneus and the right calcarine fissure were enhanced. The FC of the left orbital superior frontal gyrus with the right superior temporal gyrus and the right postcentral gyrus was enhanced， and the FC of the right parahippocampal gyrus with the right medial and lateral cingulate gyrus， right thalamus and right caudate nucleus was weakened. Correlation analysis showed that there was no significant correlation between MoCA scale score and FC based on DMN network nodes. Conclusion The DMN network was damaged in patients with acute mTBI， and the memory function was impaired. In addition， no correlation was found between FC abnormalities and MoCA scale scores in this study

Key words: mild traumatic brain injury, resting?state functional MRI, functional Magnetic Resonance Imaging, dysmnesia, functional connection

CLC Number:

R651.15

Zhe ZENG,Lin LUO,Qiang CHEN,Siqi HOU,Shengzhe. JIANG. Default mode network analysis associated with memory impairment in acute mild traumatic brain injury[J]. The Journal of Practical Medicine, 2024, 40(10): 1412-1417.

Figures/Tables 6

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References 23

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项目	急性mTBI组（n = 39）	HC组（n = 39）	U/χ²值	P值
年龄（岁）	33（29，37）	32（26，43）	752	0.932
性别（例）			< 0.001	1.0
男	21	21
女	18	18
受教育年限（年）	15（9,15）	15（12,15）	637	0.166
受伤后时间（x ± s，d）	3.97 ± 1.72
MoCA量表延迟回忆评分（x ± s，分）	2.44 ± 1.39

网络节点	节点坐标（x，y，z）
左后扣带回	-6，-43，25
右后扣带回	6，-42，22
左眶内额上回	-6，54，-7
右眶内额上回	7，52，-7
左海马	-26，-21，-10
右海马	28，-20，-10
左海马旁回	-22，-16，-21
右海马旁回	24，-15，-20

网络节点	节点坐标（x，y，z）	脑区（AAL）	群集大小（体素）	峰MNI坐标（x，y，z）	T值
左后扣带回	-6，-43，25	左楔叶	128	-15，-66，25	4.185
		右距状裂周围皮层	247	20，-78，14	3.340
左眶内额上回	-6，54，-7	右颞上回	463	60，-17，6	4.125
		右中央后回	272	57，-17，35	3.887
右海马旁回	24，-15，-20	右内侧和旁扣带脑回	566	3，0，46	-3.99
		右丘脑	258	9，-4，9	-4.16
		右尾状核	157	13，11，7	-3.52

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Default mode network analysis associated with memory impairment in acute mild traumatic brain injury

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