关键词:

长链非编码RNA, 微小RNA, mRNA, 脑缺血/再灌注损伤

Abstract:

Cerebral ischemia/reperfusion（I/R）injury secondary to ischemic stroke is associated with a high mortality and disability. Long non⁃coding RNAs（lncRNAs），one of non⁃coding RNAs，can regulate gene expression at the epigenetic ，transcriptional and post ⁃transcriptional levels. Acting as endogenous sponges of microRNAs（miRNAs），it can inhibit the negative regulation of miRNAs on mRNAs by suppressing the expression of miRNAs，which functions as a regulatory axis in mechanism. Numerous studies have found that the lncRNAs ⁃ miRNAs ⁃mRNAs regulatory axis is involved in the pathological process of cerebral I/R injury. This paper reviews the research advances in the role of the axis in cerebral I/R，and looks into the mechanism of lncRNAs and miR⁃ NAs in the treatment of ischemic cerebrovascular diseases. 

Key words:

 , lncRNA, miRNA, mRNA, cerebral ischemia/reperfusion injury