实用医学杂志 ›› 2021, Vol. 37 ›› Issue (14): 1897-1901.doi: 10.3969/j.issn.1006⁃5725.2021.14.025

• 综述 • 上一篇    下一篇

长链非编码RNA 与GSK⁃3β相关通路在 肿瘤中相互作用的研究进展

谢文杰, 张文波, 邹晨   

  1. 镇江市第一人民医院(江苏大学附属人民医院)普外科(江苏镇江 212002)

  • 出版日期:2021-07-25 发布日期:2021-07-25
  • 基金资助:
    国家自然科学基金青年基金面上项目(编号:81500193,81802409);中国博士后科学基金项目(编号:2015M571703);江苏省自然科学基金面上项目(编号:BK20161353,BK20171304);江苏省青年医学重点人才项目(编号:QN⁃RC2016454);镇江市重点研发计划社会发展面上项目(编号:SH2017026,SH2018057)

Research Advance in interactions between long non⁃coding RNA and GSK⁃3β related signaling pathways in tumors 

XIE Wenjie,ZHANG Wenbo,ZOU Chen.   

  1. Department of General Surgery,Zhengjiang First People′s Hospital,Affiliated People′s Hospital,Jiangsu University,Zhenjiang 212002,China 

  • Online:2021-07-25 Published:2021-07-25
  • Contact: ZOU Chen E⁃mail:Tigerzou@126.com
  • Supported by:


摘要:

长链非编码RNA(long non⁃coding RNA,lncRNA)是一种多功能的非编码RNA,参与调控多种 肿瘤的进展。糖原合酶激酶⁃3β(glycogen synthase kinase⁃3β,GSK⁃3β)是一种丝氨酸和苏氨酸激酶,通过Wnt/ β⁃catenin、PI3K/Akt、Notch、NF⁃κB和Hedgehog信号通路发挥重要的肿瘤调控作用。近年来不断有研究表明 lncRNA与GSK⁃3β相关通路的相互作用在多种肿瘤中发挥着重要作用,与患者预后密切相关。本文对lncRNA 与GSK⁃3β相关通路在多种肿瘤中的作用进行综述,以期为临床治疗及未来研究提供借鉴和思考。

关键词:

长链非编码RNA, GSK?3β, 信号通路, 肿瘤

Abstract:

Long non⁃coding RNA(lncRNA)is a multifunctional non⁃coding RNA involving in the regula⁃ tion of the development of a variety of tumors. GSK⁃3β is a serine and threonine kinase that plays an important role in tumor regulation through Wnt/β⁃catenin,PI3K/Akt,Notch,NF⁃κB and Hedgehog signaling pathways. In recent years,increasing studies have shown that the interactions between lncRNA and GSK⁃3β related signaling pathways play an important role in various tumors and are closely related to patient prognosis. In this paper,the roles of lncRNA and GSK ⁃ 3β related signaling pathways in various tumors are reviewed,so as to provide reference and thinking for clinical treatment and future research.

Key words:

 , lncRNA, GSK?3β, signaling pathways, tumor