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Abstract:

Lung cancer is one of the malignancies with the highest incidence and mortality among all cancers worldwide，but still no effective treatment is available. Chimeric antigen receptor gene modified⁃T（CAR⁃T） cells，a novel adoptive immunotherapy strategy，not only have been used successfully against hematological tumors， but also have opened up new approach for immunotherapy of solid tumors，including lung cancer. However，CAR⁃ T cell immunotherapy still has challenges and obstacles in the treatment of lung cancer due to the heterogeneity of solid tumors，tumor microenvironment immunosuppression，tumor target antigen escape，and off ⁃target toxicity， etc. In this review，we summarized the latest research progress on CAR⁃T cell immunotherapy for lung cancer， including CAR ⁃T cell biological characteristics，targets selection，early clinical research，therapeutic adverse effects，and proposed optimization strategies for CAR⁃T cell immunotherapy in lung cancer，aiming to provide new ideas for clinical immunotherapy for lung cancer.

Key words: lung cancer, chimeric antigen receptor gene modified?T cells, immunotherapy, tumor antigen