实用医学杂志 ›› 2023, Vol. 39 ›› Issue (13): 1647-1651.doi: 10.3969/j.issn.1006⁃5725.2023.13.009

• 临床研究 • 上一篇    下一篇

Life′s Simple 7干预减轻Her⁃2阳性乳腺癌患者 化疗相关心血管系统损害的研究 

吴军 崔伟燕 李平 张青凤 欧月珍    

  1. 广东省第二人民医院肿瘤一科（广州510317）
  • 出版日期:2023-07-10 发布日期:2023-07-10
  • 基金资助:
    广东省医学科学技术研究项目（编号：B2020134）

Life′s Simple 7 intervention to alleviate chemotherapy⁃related cardiovascular system damage in HER2 posi⁃ tive patients with breast cancer 

WU Jun，CUI Weiyan，LI Ping，ZHANG Qingfeng，OU Yuezhen.    

  1. Department of Oncology I，Guangdong Second Provincial General Hospital，Guangzhou 510317，China
  • Online:2023-07-10 Published:2023-07-10

摘要：

目的 探讨 Life′s Simple 7（LS7）干预减轻 Her⁃2 阳性乳腺癌患者根治术后化疗相关心血管 系统损害的作用。方法 将 120 例 Her⁃2 阳性并接受标准化乳腺癌化疗的患者随机等量分为对照组及 LS7 组，对照组为标准化疗方案，LS7 组为对照组基础上给予 LS7 干预 12 个月，后续通过比较两组治疗前后心血管系统损伤程度、焦虑、抑郁及生活质量等指标评价其对心血管系统损害的改善作用。结果 相较于对照组，LS7 组 LS7 总评分及 7 项心血管健康指标均优于对照组（P < 0.05），LS7 组 LVEF 较高（P < 0.05）、NT⁃proBNP 较低（P < 0.05），焦虑和抑郁评分较低（P < 0.05）、生活质量评分较高（P < 0.05）。结论 LS7 干预可显著减轻 Her⁃2 阳性乳腺癌化疗相关心血管系统损害并改善乳腺癌患者的心理状况和生活质 量，值得在临床推广。 

关键词: Life′s Simple 7, 乳腺癌, 心血管健康, 心理状况, 生活质量

Abstract:

Objective To investigate the effect of Life′s Simple 7（LS7）intervention on chemotherapy⁃ related cardiovascular system damage in HER2 positive patients with breast cancer after radical surgery. Methods A total of 120 HER2 positive patients who received standardized chemotherapy for breast cancer were randomly divided into control group and LS7 group. The control group was addressed with standard chemotherapy scheme，and LS7 group was treated with LS7 intervention for 12 months on the basis of the control group. The improvement effect of cardiovascular system damage in the two groups was evaluated by comparing the degree of cardiovascular system damage，anxiety，depression，and quality of life before and after treatment. Results Compared with the control group，the LS7 group had better overall LS7 score and 7 cardiovascular health indicators（P < 0.05）. The LS7 group had higher LVEF（P < 0.05），lower NT⁃proBNP（P < 0.05），lower anxiety and depression score（P < 0.05）， and higher quality of life score（P < 0.05）. Conclusion LS7 intervention can significantly reduce chemotherapy⁃ related cardiovascular system damage in HER2 positive breast cancer patients and improve the mental health and quality of life of breast cancer patients，which is worthy of clinical promotion. 

Key words: Life′s Simple 7, breast cancer, cardiovascular health, psychological status, quality of life

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