关键词: 主动脉缩窄,  , 血压,  , 血管内皮功能

Abstract:

Objective To observe the abnormal blood pressure in children after operation on coarctation of aorta （CoA），and explore the relationship between abnormal blood pressure and endothelial disfunction. Methods We enrolled 23 children with CoA who underwent surgery between January and October in 2010 in Guangzhou Women and Children′s Medical Center and 20 health children. According to blood pressure（BP）results during an 8⁃ year follow ⁃ up ，children with CoA were divided into a post ⁃ operative abnormal blood pressure group（CoA BP（+）group）and a post⁃operative normal blood pressure group（CoA BP（⁃）group）. All participants underwent measurements of systolic blood pressure（SBP），diastolic blood pressure（DBP），echocardiography，flow⁃ mediated dilation（FMD）of the right brachial artery，and serum soluble E⁃selectin（sE⁃selectin）at baseline（1 week after surgery）and during an 8⁃year follow⁃up（after surgery）. Results We collected data from the 8⁃year follow⁃up of 17 children with CoA and 15 health children. 41.18% of the children with CoA had abnormal blood pressure， amongst which 5 had elevated blood pressure and 2 met the hypertension standard. There were no differences in DBP among there groups at baseline and 8⁃year follow⁃up（P > 0.05）. Both CoA BP（+）children and CoA BP（-）children had decreased FMD and higher serum levels of sE⁃selectin than health children at baseline and during the 8⁃year follow⁃up（P < 0.05）. And CoA BP（+）children had decreased FMD and higher serum levels of sE⁃selectin than CoA BP（-）children at baseline and 8⁃year follow⁃up（P < 0.01）. Conclusion Some children after operation on CoA had abnormal BP during a long⁃term follow⁃up. Compared with children with normal BP after CoA surgery，chil⁃ dren with abnormal BP after CoA operation had more obvious vascular endothelial dysfunction. 

Key words:

coarctation of the aorta, blood pressure, vascular endothelial function