激光联合聚多卡醇泡沫硬化剂法治疗静脉畸形的疗效

doi:10.3969/j.issn.1006⁃5725.2021.24.018

实用医学杂志 ›› 2021, Vol. 37 ›› Issue (24): 3188-3192.doi: 10.3969/j.issn.1006⁃5725.2021.24.018

激光联合聚多卡醇泡沫硬化剂法治疗静脉畸形的疗效

张一飞宋燕苗仁英王彦军付一群郎玉昶刘万里齐超然张志敏

郑州大学第一附属医院大血管外科（郑州 450052）

出版日期:2021-12-25 发布日期:2021-12-25
通讯作者: 宋燕 E⁃mail：fccsongy3@zzu.edu.cn
基金资助:
河南省高等学校重点科研项目（编号：21A320042）

The efficacy of laser combined with polidocanol foam sclerotherapy for venous malformations

ZHANG Yifei，SONG Yan，MIAO Renying，WANG Yanjun，FU Yiqun，LANG Yuchang，LIU Wanli，QI Chaoran，ZHANG Zhimin.

Department of Macrovascular Surgery，the First Affiliated Hospital of Zhengzhou University，Zhengzhou450052，China

Online:2021-12-25 Published:2021-12-25
Contact: SONG Yan E⁃mail：fccsongy3@zzu.edu.cn

摘要/Abstract

摘要：

目的比较激光联合聚多卡醇泡沫硬化剂法和单纯泡沫硬化剂法治疗静脉畸形的有效性和安全性。方法回顾性分析 2019 年 5 月至 2020 年 10 月郑州大学第一附属医院收治的 96 例静脉畸形患者资料，其中将激光联合泡沫硬化剂治疗51例患者纳入研究组，单纯泡沫硬化剂治疗45例患者纳入对照组，术后随访6个月，根据MRI评估治疗前后病灶大小变化，对比术前及术后疼痛视觉模拟评分（VAS）的变化，记录随访中的并发症，比较两组的有效性及安全性，并继续进行远期随访。结果 96例患者术后VAS评分为（2.49 ± 1.57），较术前（4.25 ± 2.09）显著降低（P < 0.001），说明患者疼痛症状明显改善。根据术中造影对患者行Puig分型，研究组中PuigⅠ、Ⅱ型患者的有效率与对照组相比差异无统计学意义（P > 0.05）；研究组中Puig Ⅲ、Ⅳ型患者的有效率与对照组的差异有统计学意义（P < 0.05），且研究组有效率更高。两组并发症较少且均可恢复，对比无明显差异。结论激光联合泡沫硬化剂法治疗静脉畸形是一种安全有效的治疗方式，尤其对于回流静脉丰富的静脉畸形（PuigⅢ、Ⅳ型），激光联合泡沫硬化剂法较单纯泡沫硬化剂法效果更佳。

关键词:

, 激光, 泡沫硬化剂, 静脉畸形, 聚多卡醇, 血管畸形, 血管瘤

Abstract:

Objective To compare the effectiveness and safety of laser combined with polidocanol foam sclerosant with those of foam sclerosant alone in the treatment of venous malformations. Methods The data on 96 patients with venous malformations，who had admitted to the first affiliated hospital of Zhengzhou University from May 2019 to October 2020，were retrospectively analyzed. 51 patients receiving laser combined with foam sclero⁃ therapy were included in the study group，while 45 undergoing foam sclerotherapy alone were assigned to the control group. A 6⁃month follow⁃up was conducted after the procedure. The changes in the size of the lesions were assessed after treatment according to the images on MRI. The visual analogue scale（VAS）of pain was compared between the baselines and the posttreatment scores. The complications were recorded during the follow⁃up ，the effectiveness and safety were compared between the two groups ，and the long ⁃term follow ⁃up was continued. Results The posttreatment VAS score of 96 patients was significantly lower than the baselines（2.49 ± 1.57 vs. 4.25 ± 2.09，P < 0.001），indicating that pain symptoms were significantly improved in the patients. Based on intra⁃ operative angiography，the Puig classification was performed in the patients. There was no significant difference in the effective rate between the PuigI or Ⅱ patients in the study group and those in the control group（P > 0.05）； while the effective rate differed significantly between the PuigⅢ or Ⅳ patients in the study group than those in the control group（P < 0.05），and it was more efficient in the study group. The patients in both groups had fewer compli⁃ cations and there was no significant difference between the two groups，and the complications could be eliminated. Conclusions Laser combined with foam sclerosant is a safe and effective way to treat venous malformations，espe⁃ cially for venous malformations with abundant reflux veins（PuigⅢ，Ⅳ），and the combination therapy is more effective than the therapy with foam sclerosant alone.

Key words:

laser, foamsclerosant, venous malformation, polidocanol, vascular malformation, hemangioma

张一飞宋燕苗仁英王彦军付一群郎玉昶刘万里齐超然张志敏.

激光联合聚多卡醇泡沫硬化剂法治疗静脉畸形的疗效

[J]. 实用医学杂志, 2021, 37(24): 3188-3192.

ZHANG Yifei, SONG Yan, MIAO Renying, WANG Yanjun, FU Yiqun, LANG Yuchang, LIU Wanli, QI Chaoran, ZHANG Zhimin.. The efficacy of laser combined with polidocanol foam sclerotherapy for venous malformations [J]. The Journal of Practical Medicine, 2021, 37(24): 3188-3192.

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激光联合聚多卡醇泡沫硬化剂法治疗静脉畸形的疗效

The efficacy of laser combined with polidocanol foam sclerotherapy for venous malformations

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