实用医学杂志 ›› 2021, Vol. 37 ›› Issue (8): 1072-1079.doi: 10.3969/j.issn.1006⁃5725.2021.08.022

• 医学检查与临床诊断 • 上一篇    下一篇

神经节细胞复合体对糖尿病视网膜病变诊断的意义

沈培清, 李永蓉,范玲玲
  

  1. 1 合肥市第二人民医院眼科(合肥230011);2 安徽医科大学第一附属医院眼科(合肥230022)
  • 出版日期:2021-04-25 发布日期:2021-04-25
  • 基金资助:
    2019 年安徽省自然科学基金项目(编号:1908085QH381);2019 年度蚌埠医学院自然科学重点项目(编号:BYKY2019308ZD)

Significance of ganglion cell complex in the diagnosis of diabetic retinopathy

SHEN Peiqing,LI Yongrong,FAN Lingling. 
  

  1. Department of Ophthalmology,the Second People′s Hospital of Hefei,Hefei 230011,China
  • Online:2021-04-25 Published:2021-04-25

摘要:

目的 观察糖尿病患者视网膜黄斑区神经节细胞复合体(ganglion cell complex,GCC)厚度变化,分析 GCC 厚度检测对早期糖尿病视网膜病变诊断的意义。方法 回顾性分析糖尿病患者 83 83 眼),其中无糖尿病视网膜病变(no diabetic retinopathy,NDR)50 例(50 眼)设为 NDR 组,另 33 33 眼)确诊为轻中度非增殖性糖尿病视网膜病变(non⁃proliferative diabetic retinopathy,NPDR)设为 NPDR 组,再取 50 例(50 眼)无糖尿病的健康人设为对照组,采用光学相干断层扫描成像(optical coherence tomography,OCT)进行 GCC 厚度检测,对数据进行统计分析。结果 与对照组相比,NDR S3、N3 S6、N6 对应分区 GCC 厚度变薄(t = 0.049、0.044、0.040、0.049,均 P < 0.05),NPDR S3、N3、S6、N6、I6 对应分区 GCC 厚度变薄(t = 0.015、0.016、0.043、0.037、0.042,均 P < 0.05),差异均具有统计学意义(P < 0.05)。结论 NDR、NPDR 患者 GCC 厚度较健康人明显变薄,通过 OCT 检测可发现糖尿病患者早期视网膜病变。

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Abstract:

Objective To observe the thickness changes of ganglion cell complex in macular area of patients with diabetes,and to analyze its significance in the diagnosis of early diabetic retinopathy. Methods Eighty ⁃three patients(83 eyes)with diabetes were retrospectively analyzed,among whom 50 patients(50 eyes without diabetic retinopathy(NDR)were assigned to NDR group,and the other 33 cases(33 eyes)with mild to moderate non⁃proliferative diabetic retinopathy(NPDR)were assigned to NPDR group. A total of 50 healthy people (50 eyes)were selected as the control group,and the thickness of GCC was detected by optical coherence tomogra⁃ phy(OCT),and the data were analyzed. Results Compared with the control group,the thickness of GCC of S3 N3,S6 and N6 sectors in NDR group were thinner(t = 0.049,0.044,0.040 and 0.049,P < 0.05),while those of S3,N3,S6,N6 and I6 sectors in NPDR group were thinner(t = 0.015,0.016,0.043,0.037,0.042,P < 0.05), and the difference was statistically significant(P < 0.05). Conclusion The thickness of GCC in patients with NDR and NPDR were significantly thinner than those of the healthy people. Early retinopathy in diabetic patients could be found through OCT detection.

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