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Objective To understand the characteristics of HIV infection among young blood donors aged 18 to 25 in this area，It provides a basis for the development of recruitment strategies for blood donors and reduces the risk of HIV transmission through blood transfusion. Methods A total of 2 973 685 samples of unpaid blood donors were tested for HIV by two ELISA reagents and nucleic acid reagents from two different manufacturers and the third party agencies（guangzhou golden field medical inspection center）confirmed by western blot method for HIV positive people. The characteristics of HIV infection among young blood donors aged 18 ~ 25 years were analyzed statistically. Results Among the 2 973 685 blood donors，736 cases were confirmed to be anti ⁃HIV positive. Among the 1 561 660 young blood donors aged 18⁃25，289 were confirmed anti⁃HIV cases，accounting for 39.27% of the total confirmed cases. Among 289 HIV ⁃confirmed young blood donors，males were significantly higher than females（P < 0.01）. Other distribution characteristics were as follows：218 patients（75.45%）donated blood for the first time，and 4.15%（4.15%）donated blood for more than 3 times. Street and work groups accounted for 84.43% and 15.56%，respectively；There were 286 cases（98.96%）who donated whole blood，and the other 3 cases were component blood donation.35.99% of the city′ s household registration and 36.68 of the provinces； Students and non⁃school blood donors accounted for 24.57% and 60.9%，respectively. Conclusion Among blood donors aged 18⁃25 years in Guangzhou，the risk of HIV infection among male blood donors is much higher than that of female blood donors. Fixed blood donors，group blood donors and school students are the groups with low risk of HIV infection；in the recruitment of blood donation in this region，we should strengthen the health consulta⁃tion on male homosexuality and HIV publicity among young people to ensure the safety of blood for clinical use. 

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