关键词: 纵向弛豫成像, 磁共振, 肥厚型心肌病, 诊断

Abstract:

Objective To quantitatively analyze the fibrosis characteristics of hypertrophic cardiomyopathy（HCM）by T1 mapping technique，and analyze the basic data of HCM patients. Methods Twenty⁃eightcases withHCM patients and 16 cases（normal group）were examined with T1 mapping sequence，delayed enhanced scan andlaboratory examination. The initial T1 values of hypertrophic and non⁃hypertrophic myocardium in case group，normal group and case group were statistically analyzed.According to delayed enhanced scan，patients were dividedinto negative group and positive group. The differences of myocardial T1 and basic data between LGE negative，LGE positive and normal groups were compared. The ROC curve was constructed to analyze the diagnostic value ofT1 value in distinguishing LGE negative from normal group，LGE positive from normal group. Results The nativeT1 value in the HCM group were larger than those in the normal group. The initial T1 values of hypertrophic aerawere larger than those in non⁃hypertrophic myocardium. The difference was statistically significant（P < 0.001）.There were significant differences among LGE negative，LGE positive and normal groups（P < 0.001）. There wasno significant difference in ejection fraction and NT⁃proBNPamong the two groups，but the maximum short diameterof LGE negative group was lower than that of LGE positive group，and the maximum long diameter was opposite.The sensitivity and accuracy of T1 value in distinguishing LGE negative from normal group were more than 85%，respectively，and the accuracy were 93.1% between LGE positive and normal groups. Conclusion T1 mappingtechnique can quantify the degree of myocardial fibrosis. The value of T1 is related to the degree of myocardial hyper⁃trophy.

Key words: T1 mapping, magnetic resonance, hypertrophic cardiomyopathy, diagnosis