The Journal of Practical Medicine ›› 2022, Vol. 38 ›› Issue (1): 96-100.doi: 10.3969/j.issn.1006⁃5725.2022.01.018

• Medical Examination and Clinical Diagnosis • Previous Articles     Next Articles

Classification criteria of EULAR/ACR ⁃ 2019，SLICC ⁃2012，and ACR ⁃1997：A comparative study 

LIN Chaoqun*，WANG Haihong，SHA Luying，WANG Yanqing，HUANG Honglian，SHEN Jie，SONG Juyan，SHEN Xiaoping.   

  1. Department of Dermatology，Guiyang First People′s Hospital，Guiyang 550000，China
  • Online:2022-01-10 Published:2022-01-10

Abstract:

Objective To compare the classification criteria for systemic lupus erythematosus（SLE）by the European League Against Rheumatism/American College of Rheumatology ⁃ 2019（EULAR/ACR ⁃2019），the International Cooperative Clinical Organization ⁃2012（SLICC ⁃2012）and the American College of Rheumatology ⁃ 1997（ACR⁃1997）and evaluate the diagnostic values of the three classification criteria in combination with practical diagnosis of clinical cases. Methods A total of 73 cases diagnosed with SLE in the Affiliated Hospital of Guizhou Medical University from January 2014 to December 2019 were enrolled as the SLE goup，and another group of 82 cases diagnosed with other connective histdiseases were assigned as the control group. The data from various clinical indica⁃ tors and immunological indicators were collected and analyzed in terms of the differences in sensitivity，specificity and area under ROC curve between the three SLE classification criteria. Results There were significant differences in the sensitivity and specificity between EULAR/ACR-2019,SLICC-2012 and ACR-1997,respectively(95.89% vs. 98.63% vs. 73.97%；92.68% vs. 84.15% vs. 98.78%). The sensitivity of ACR⁃1997 was the lowest,and the speci⁃ ficity of SLICC⁃2012 was the lowest(P<0.001).There were significant differences in missed diagnosis rate and misdiagnosis rate between EULAR/ACR⁃2019，SLICC⁃2012 and ACR⁃1997，ACR⁃1997 having the highest missed diagnosis rate and the lowest misdiagnosis rate（P < 0.05）. The areas under the ROC curve（AUC）of EULAR/ACR⁃ 2019，SLICC ⁃2012，and ACR ⁃1997 were 0.943，0.914 and 0.864，respectively，with statistically significant dif⁃ fernces between them（P = 0.0044），but the AUC was not significant between SLICC⁃2012 and EULAR/ACR⁃2019， ACR⁃1997（P > 0.005）. Conclusion The SLE diagnostic value of EULAR/ACR⁃2019 is better than ACR⁃1997 and SLICC⁃2012 has no significant advantage over EULAR/ACR⁃2019 and ACR⁃1997. The combination of EULAR/ACR⁃ 19 with SLICC⁃12 may be more advantegeous in the early diagnosis of SLE and the direction for its treatment.

Key words:

systemic lupus erythematosus, classification criteria, comparative study, early diagnosis