Abstract:

Objective To investigate the predictive value of C ⁃ reactive protein/albumin ratio（CAR）in acute exacerbation of bronchiectasis. Methods 107 patients were selected as the case group and 97 healthy outpatients were selected as the control group at the same time. The expression levels of C⁃reactive protein（CRP） and albumin（ALB）in serum of all subjects were detected，and the ratio（CAR）of CRP and ALB were calculated. Spearman correlation analysis，ordered Logistic regression analysis and ROC curve analysis were used to explore the correlation and predictive value between these three indicators and the degree of disease. Results （1）The serum CRP level in case group was significantly higher than that in control group，the serum ALB level in case group was significantly lower than that in control group，and the serum CAR level in case group was significantly higher than that in control group（all P < 0.01）.（2）Serum CRP and CAR were found to be positively correlated with BSI，while serum ALB was found to be negatively correlated with BSI（all P＜0.01）.（3）ALB and CAR were risk indicators for exacerbation of bronchiectasis（all P < 0.01）. CAR outperformed ALB in terms of area under the curve，sensitivity，and specificity. Conclusion CAR has good predictive efficacy for severe bronchiectasis，and it is suggested that CAR would be used as a supplement to other score systems，which is helpful for clinicians to quickly judge the severity of patients′ disease early and develop the best therapeutic regimen. 

Key words:

bronchiectasis, acute exacerbation, c?reactive protein, albumin, c?reactive protein/ albumin ratio