Abstract:

Objective To investigate and analyze the effect of intracavitary infusion of elemene combined with nedaplatin on clinical efficacy and quality of life of patients with malignant ascites. Methods Eighty ⁃five patients with malignant ascites from February 2014 to January 2017 were randomly divided into observation group （n = 44）and control group（n = 41）. The control group was given intracavitary injection of nedaplatin and dexa⁃ methasone and the observation group was treated with elemene injection on the basis of the control group. The two groups were compared in terms of remission of pleural and ascites，changes in quality of life，adverse reactions and living conditions. Results The total effective rate of relieving pleural and ascites in the observation group was significantly higher than that in the control group（P < 0.05）. After treatment，the scores of the six dimensions of general health，emotional and social functions，physiological functions，vitality，physiological functions and men⁃ tal health in relation with the quality of life in the observation group were all significantly higher than those in the control group（P < 0.05）. The living conditions of patients in the observation group was significantly better than that in the control group（P < 0.05）. Conclusion Elemene combined with nedaplatin intracavitary injection in the treatment of malignant ascites is more effective clinically，more tolerable for the patients and conducive to their improved quality of life. Moreover，it can significantly improve their long⁃term survival and prognosis. Therefore it is worthy of clinical application.

Key words:

elemene, nedaplatin, intracavitary perfusion, malignant ascites, efficacy, quality of life