妊娠早期阶段卵黄囊大小形态学及内径变化对早期流产的预测价值

doi:10.3969/j.issn.1006-5725.2026.01.020

Abstract

Abstract:

Objective To analyze the predictive value of yolk sac size morphology and inner diameter changes in early pregnancy on early abortion. Methods A total of 120 pregnant women with early pregnancy admitted to the hospital from January 2023 to December 2024 were selected as research subjects （118 cases were finally included and 2 cases were lost to follow-up）. According to the pregnancy outcomes， they were divided into normal pregnancy group （n = 82） and early abortion group （n = 36）. Baseline data and yolk sac parameters were compared between the two groups. Multivariate Logistic regression analysis was used to analyze the risk factors affecting early abortion， and ROC curve was used to evaluate the predictive value of yolk sac size morphology and inner diameter changes in early pregnancy on early abortion. Results The proportion of age ≥ 35 years old in early abortion group was significantly higher than that in the normal pregnancy group （P < 0.05）. The yolk sac diameter of each gestational week in early abortion group was significantly larger than that in normal pregnancy group （P < 0.05）. The proportion of yolk sac deletion， proportion of abnormal yolk sac diameter and proportion of abnormal yolk sac morphology were significantly higher in early abortion group than those in normal pregnancy group （P < 0.05）. Multivariate Logistic regression analysis showed that age ≥ 35 years old （OR = 1.664， 95%CI： 1.272 ~ 2.176）， yolk sac deletion （OR = 23.927， 95% CI： 9.561 ~ 59.876）， abnormal yolk sac diameter （OR = 30.114， 95%CI： 13.092 ~ 69.269） and abnormal yolk sac morphology （OR = 16.844， 95% CI： 6.359 ~ 44.617） were risk factors for early abortion. ROC curve analysis showed that the abnormal yolk sac morphology had the highest value on predicting early abortion （AUC = 0.862）， followed by abnormal yolk sac diameter （AUC = 0.669） and yolk sac deletion （AUC = 0.611）. Conclusion The abnormal morphology of yolk sac in early pregnancy can be used as an important indicator to predict early abortion and provide scientific basis for early intervention.

Key words: early abortion, yolk sac, morphology, early pregnancy, predictive value

CLC Number:

R714.21

Jingrui WEI,Qiaofang LIU,Youyun LI,Shan WANG,Shuai XU. Predictive value of yolk sac size morphology and inner diameter changes in early pregnancy on early abortion[J]. The Journal of Practical Medicine, 2026, 42(1): 152-156.

Figures/Tables 6

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References 25

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组别	例数	年龄/［例（%）］		BMI/（kg/m²）	孕周/周	孕产史/［例（%）］
组别	例数	≥ 35岁	< 35岁	BMI/（kg/m²）	孕周/周	初产	经产
正常妊娠组	82	28（34.15）	54（65.85）	23.23 ± 2.88	5.49 ± 0.50	50（60.98）	32（39.02）
早期流产组	36	21（58.33）	15（41.67）	23.84 ± 3.12	5.37 ± 0.49	23（63.89）	13（36.11）
t/χ²值		6.027		1.033	1.208	0.090
P值		0.014		0.304	0.230	0.764

组别	例数	5 ~ 6周	6 ~ 7周	7 ~ 8周	8 ~ 9周	9 ~ 10周	10 ~ 12周
正常妊娠组	82	3.38 ± 0.29	4.31 ± 0.70	6.07 ± 1.04	4.93 ± 0.62	4.45 ± 0.58	3.51 ± 0.54
早期流产组	36	3.45 ± 2.03	3.78 ± 2.05	4.03 ± 2.21	4.37 ± 2.38	4.14 ± 2.27	3.66 ± 2.03
t值		0.275	2.078	6.856	1.974	1.412	0.630
P值		0.784	0.040	< 0.001	0.051	0.256	0.530

指标	正常妊娠组（n = 82）	早期流产组（n = 36）	χ²值	P值
卵黄囊缺失			-	< 0.001
是	0（0.00）	8（22.22）
否	82（100.00）	28（77.78）
卵黄囊直径异常			11.605	0.001
是	27（32.93）	24（66.67）
否	55（67.07）	12（33.33）
卵黄囊形状异常			59.194	< 0.001
是	9（10.98）	30（83.33）
否	73（89.02）	6（16.67）

指标	单因素		多因素
指标	OR（95%CI）	P值	OR（95%CI）	P值
年龄≥ 35岁	2.700（1.208 ~ 6.037）	0.016	1.664（1.272 ~ 2.176）	< 0.001
卵黄囊缺失	-	< 0.001	23.927（9.561 ~ 59.876）	< 0.001
卵黄囊直径异常	4.074（1.773 ~ 9.362）	0.001	30.114（13.092 ~ 69.269）	< 0.001
卵黄囊形状异常	40556（13.272 ~ 123.928）	< 0.001	16.844（6.359 ~ 44.617）	< 0.001

指标	AUC	95%CI	敏感度/%	特异度/%
卵黄囊缺失	0.611	0.493 ~ 0.729	22.22	100.00
卵黄囊直径异常	0.669	0.562 ~ 0.776	66.67	67.07
卵黄囊形状异常	0.862	0.781 ~ 0.943	83.33	89.02

Predictive value of yolk sac size morphology and inner diameter changes in early pregnancy on early abortion

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