黄蜀葵花制剂防治急性放射性心肌损伤的效果

doi:10.3969/j.issn.1006-5725.2025.17.004

Abstract

Abstract:

Objective To investigate the protective effects and potential mechanisms of the preparation of Abelmoschus manihot （L.） Medik （Jiahua Tablet） against acute radiation-induced myocardial injury， based on myocardial injury markers （sST2， cTnI） and oxidative stress damage-related indicators （SOD， MDA）， and to provide new avenues for the prevention and treatment of radiation-induced heart disease （RIHD）. Methods Sixty-nine patients with thoracic malignant tumor who received radiotherapy at the department of radiation oncology in Hospital Affiliated to Nanjing University of Chinese Medicine from December 2023 to November 2024 were enrolled in the study. Participants were randomly divided into control group （n = 38） and observation group （n = 31）. The control group received standard radiotherapy in conjunction with conventional medications for RIHD， while the observation group was additionally administered Jiahua Tablet alongside the same regimen. Both groups took medications continuously for 1 month. Changes in serum levels of sST2， cTnI， SOD， and MDA were compared between the two groups 3 days prior to radiotherapy and 7 days after radiological therapy. Results On day 7 post-radiotherapy， the levels of sST2 and cTnI in the control group were highly elevated， showing statistically significant difference （P < 0.01）. In contrast， the levels of sST2 and cTnI in the observation group showed only mild elevation， and no statistically significant difference was observed （P > 0.05）. Between-group analysis demonstrated that post-treatment sST2 and cTnI levels in the observation group were substantially lower compared to those in the control group， indicating statistically significant difference （P < 0.05）. After treatment， SOD level in the control group was considerably lower compared to its pre-treatment level， and marked statistical significance was observed （P < 0.01）. SOD level in the observation group demonstrated a downward trend compared to baseline value， indicating no statistical significance（P > 0.05）. Between-group analysis demonstrated that post-treatment SOD level in the observation group was substantially elevated compared to that in the control group， indicating a highly significant disparity（P < 0.05）. After treatment， MDA level in the control group was considerably higher compared to its pre-treatment level， and a marked statistical significance was observed （P < 0.05）， whereas MDA level in the observation group showed only a mild increase compared to baseline value， with no statistically significant difference （P > 0.05）.Between-group analysis demonstrated that post-treatment MDA level in the observation group was substantially lower compared to that in the control group， demonstrating a remarkably statistically significant difference （P < 0.01）. Conclusion The preparation of Abelmoschus manihot （L.） Medik （Jiahua Tablet） effectively inhibits acute radiation-induced myocardial injury， with its potential mechanism closely linked to the suppression of oxidative stress responses.

Key words: Abelmoschus manihot （L.） Medik, Jiahua tablet, oxidative stress, acute radiation-induced myocardial injury, sST2, cTnI, SOD, MDA

CLC Number:

R541

Wenli YANG,Tong BAO,Xin LIN,Ruge NIU,Zhongchi XU,Yunhe ZHAO. Prevention and treatment of acute radiation⁃induced myocardial injury by the preparation of Abelmoschus manihot （L.） Medik （Jiahua Tablet）[J]. The Journal of Practical Medicine, 2025, 41(17): 2631-2636.

Figures/Tables 4

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References 31

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项目	观察组（n = 31）	对照组（n = 38）	χ²/t值	P值
性别/例			1.875	0.171
男	19	17
女	12	21
年龄/岁	69.00（58.00， 75.00）	67.00（55.50， 75.00）	-0.226	0.821
身高（x ± s）/cm	164.26 ± 7.53	160.50 ± 8.54	1.916	0.060
体质量（x ± s）/kg	64.03 ± 9.49	61.80 ± 13.29	0.784	0.436
心率（次/min）	78.00（72.00， 88.00）	76.50（74.00， 83.50）	-0.283	0.777
SBP（x ± s）/mmHg	125.03 ± 14.62	120.55 ± 16.75	1.169	0.246
DBP（x ± s）/mmHg	76.61 ± 9.18	76.95 ± 11.70	-0.130	0.897
Scr/（μmol/L）	70.00（54.00， 82.80）	62.65（54.40， 74.98）	-0.508	0.611
Urea/（mmol/L）	5.19（4.21， 6.32）	5.77（4.24， 6.81）	-0.697	0.486
AST/（U/L）	18.00（15.00， 26.00）	20.00（16.00， 23.50）	-1.814	0.070
ALT/（U/L）	19.00（10.00， 26.00）	12.50（9.75， 21.25）	-1.228	0.219

组别	sST2				cTnI
组别	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值
观察组（n = 31）	140.34 ± 66.64	144.99 ± 43.97	-0.781	0.441	3.56 ± 1.64	3.69 ± 0.81	-0.532	0.599
对照组（n = 38）	144.18 ± 44.69	164.27 ± 31.15	-2.830	0.007	3.46 ± 1.63	4.21 ± 1.18	-3.335	0.002
t值	-0.286	-2.128			0.246	-2.078
P值	0.776	0.037			0.806	0.042

组别	治疗前	治疗后	t值	P值
观察组（n = 31）	126.45 ± 26.13	124.61 ± 23.09	0.428	0.671
对照组（n = 38）	124.21 ± 21.96	112.00 ± 22.35	3.803	0.001
t值	0.387	2.298
P值	0.700	0.025

组别	治疗前	治疗后	t值	P值
观察组（n = 31）	1 647.92 ± 748.93	1 665.32 ± 598.23	-0.163	0.871
对照组（n = 38）	1 882.01 ± 553.82	2 088.75 ± 635.16	-2.240	0.031
t值	-1.491	-2.827
P值	0.141	0.006

Prevention and treatment of acute radiation⁃induced myocardial injury by the preparation of Abelmoschus manihot （L.） Medik （Jiahua Tablet）

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