外泌体蛋白、mRNA及非编码RNA调节肝癌发生和发展的研究进展

doi:10.3969/j.issn.1006-5725.2024.06.004

Abstract

Abstract:

Exosomes are extracellular vesicles commonly detected in numerous body fluids and contain a variety of components such as proteins， nucleic acids， lipids， and metabolites. These components enable exosomes to mediate intercellular communication and impact diverse cellular processes. Recently， research has highlighted that exosomes have a significant regulatory role in numerous aspects of hepatocellular carcinoma （HCC） occurrence， development， and drug resistance. Non-coding RANs， a crucial component of exosomes， can regulate the HCC tumour microenvironment with a direct impact on biological behaviours such as tumour growth， metastasis， angiogenesis， and immunomodulation. To this end， exosomes present an interesting avenue for further research in the field of HCC therapy. It is anticipated to become a novel diagnostic， prognostic marker， or therapeutic target for hepatocellular carcinoma （HCC）. Our review of the role played by exosomal components in HCC progression over the last five years aims to furnish references and innovative perspectives for early diagnosis， prognosis， and treatment of HCC.

Key words: exosomes, hepatocellular carcinoma, non-coding RNA, diagnosis, prognosis, treatment

CLC Number:

R735.7

Yuxin CHENG,Liang LIU,Shiyu DONG,Shengchao LI,Meng ZHANG. Research advances in exosomal proteins， mRNA and non⁃coding RNA regulation of Hepatocellular Carcinoma[J]. The Journal of Practical Medicine, 2024, 40(6): 748-755.

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Research advances in exosomal proteins， mRNA and non⁃coding RNA regulation of Hepatocellular Carcinoma

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