WD重复域蛋白5在宫颈癌组织中的表达及其与患者临床病理特征的关系

doi:10.3969/j.issn.1006-5725.2024.02.008

Abstract

Abstract:

Objective To investigate the expression of WD repeat-containing protein 5 （WDR5） in cervical cancer tissue and its relationship with clinical pathological characteristics and prognosis of patients. Methods 105 CA patients admitted to our hospital from January 2018 to March 2020 were included as the study subjects， the cancer tissue and adjacent tissue samples of patients were collected， Immunohistochemical staining and Western blot were used to detect the level of WDR5 in CA tissue and adjacent cancer tissues. Immunohistochemistry and Western blot were used to determine the level； Survival analysis was conducted using the Kaplan Meier method； The influencing factors of patient prognosis were analyzed through Cox regression. Results Among 105 CA tissue samples， the positive expression rate of WDR5 （WDR5 positive cases/total cancer tissue cases） was 68.57% （72/105）， which was higher than 22.86% （24/105） in adjacent cancer tissues （P < 0.05）； Compared to adjacent tissues （1.00 ± 0.11）， the expression level of WDR5 was higher in CA tissues （4.66 ± 0.98）（t = 38.030， P < 0.05）. The expression level of WDR5 is related to the degree of differentiation， TNM staging， and lymph node metastasis （P < 0.05）； The survival rate of WDR5 positive expression was 65.28% （47/72） lower than that of negative expression of 90.91% （30/33）（Log rank χ² = 6.732， P = 0.009）； TNM staging， WDR5， degree of differentiation， and lymph node metastasis are all influencing factors for patient prognosis （P < 0.05）. Conclusion The expression of WDR5 is elevated in cervical cancer tissues， and its changes are closely related to TNM staging， differentiation， lymph node metastasis， and prognosis in cervical cancer patients.

Key words: cervical cancer, WD repeat-containing protein 5, prognosis, pathological characteristics

CLC Number:

R737.33

Pixi WEI,Yu DENG,Cailing ZHAO,Liu XU,Min ZHANG. The expression of WDR5 in cervical cancer tissue and its relationship with clinical and pathological characteristics of patients[J]. The Journal of Practical Medicine, 2024, 40(2): 169-173.

Figures/Tables 6

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Tab.2

References 26

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资料	例数	WDR5		χ ² 值	P值
资料	例数	阳性	阴性	χ ² 值	P值
年龄				1.200	0.273
> 45岁	56	41（73.21）	15（26.79）
≤ 45岁	49	31（63.27）	18（36.73）
病理类型				0.145	0.704
鳞癌	77	52（67.53）	25（32.47）
腺癌	28	20（71.43）	8（28.57）
TNM分期				8.277	0.004
Ⅰ-Ⅱ	74	44（59.46）	30（40.54）
Ⅲ	31	28（90.32）	3（9.68）
分化程度				8.804	0.003
中、高	64	37（57.81）	27（42.19）
低	41	35（85.37）	6（14.63）
淋巴结转移				4.643	0.031
是	21	19（90.48）	2（9.52）
否	84	53（63.10）	31（36.90）
肿瘤直径				0.118	0.731
≥ 4 cm	63	44（69.84）	19（30.16）
< 4 cm	42	28（66.67）	14（33.33）
浸润深度				1.277	0.258
T1?T2	75	49（65.33）	26（34.67）
T3?T4	30	23（82.50）	7（17.50）
肌层浸润				1.373	0.241
有	47	35（74.47）	12（25.53）
无	58	37（63.79）	21（36.21）

因素	单因素分析			多因素分析
因素	OR	95%CI	P值	OR	95%CI	P值
年龄（> 45岁 vs. ≤ 45岁）	0.523	0.707 ~ 4.028	0.239	-	-	-
病理类型（鳞癌 vs. 腺癌）	0.129	0.770 ~ 1.680	0.518	-	-	-
TNM分期（Ⅲ vs. Ⅰ-Ⅱ）	1.241	1.342 ~ 8.916	0.010	1.641	1.990 ~ 13.370	0.001
分化程度（低 vs. 中、高）	1.672	2.044 ~ 13.857	0.001	1.520	3.059 ~ 6.830	0.000
淋巴结转移（是 vs. 否）	1.107	1.252 ~ 7.305	0.014	0.935	1.253 ~ 5.181	0.010
肿瘤直径（≥ 4 cm vs. < 4 cm）	0.159	0.437 ~ 3.142	0.753	-	-	-
浸润深度（T3 - T4 vs. T1 - T2）	1.359	0.707 ~ 2.610	0.356	-	-	-
肌层浸润（有 vs. 无）	0.590	0.761 ~ 4.279	0.181	-	-	-
WDR5（阳性 vs. 阴性）	1.218	1.944 ~ 5.876	0.000	1.971	3.653 ~ 14.094	0.000

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The expression of WDR5 in cervical cancer tissue and its relationship with clinical and pathological characteristics of patients

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