Abstract:

Objective To explore the clinical value of cattle encephalon glycoside and ignotin combined with meclofenoxate in the treatment of acute cerebral hemorrhage（ACH）. Methods A total of 123 ACH patients in our hospital were selected and divided into 3 groups according to the random number table method，41 cases in each group. The control group A was given cattle encephalon glycoside and ignotin，the control group B was given meclofenoxate，and the observation group was given the combined treatment of cattle encephalon glycoside and ignotin and meclofenoxate. The clinical efficacy，the volume of brain edema，the expression levels of serum MMP⁃2/ 9，TSP⁃1/2，neural related factors，neurological deficit（NIHSS）score，and modified Rankin scale（mRS）score before and after treatment were compared among the three groups. Results The total effective rate of in the obser⁃ vation group was higher than and in the control groups A and B（95.12% vs. 75.61%、78.05%，P＜0.05）. After treatment，the volume of brain edema in the observation group was lower than that in the control groups A and B， the serum levels of MMP⁃2/9，TSP⁃1/2，NSE，NGF，and GFAP were lower than those in control groups A and B， and BDNF levels were higher than those in control groups A and B（P < 0.05）. The NIHSS and mRS of the obser⁃ vation group after treatment were lower than those of the control groups A and B（P < 0.05）. Conclusion The combination of cattle encephalon glycoside and ignotin and meclofenoxate is effective in the treatment of ACH， which can reduce serum MMP ⁃ 2/9 and TSP ⁃ 1/2 levels，regulate nerve ⁃ related factors，promote the recovery of nerve function，and improve the prognosis.

Key words:

acute cerebral hemorrhage, cattle encephalon glycoside and ignotin, meclofenoxate, MMP?2/9, TSP?1/2, nerve?related factors