糖脂代谢指标联合抗磷脂抗体对动脉粥样硬化患者预后的预测价值

doi:10.3969/j.issn.1006-5725.2024.03.008

Abstract

Abstract:

Objective To explore the correlation of glucose and lipid metabolism indicators combined with antiphospholipid antibodies with the prognosis of patients with atherosclerosis. Methods A total of 128 patients with atherosclerosis treated in our hospital from April 2021 to March 2023 were selected as study group， and 48 healthy individuals as control group. Glycolipid metabolism indexes and antiphospholipid antibody level of the two groups were compared， and the predictive value of glycolipid metabolism indexes， antiphospholipid antibodies and combined detection for the prognosis of patients with atherosclerosis were analyzed by ROC. Results TC， TG， ACL， and anti-β2-GP1 in the study group was higher than that in the control group （P < 0.05）. The study group was divided into two sub-groups according to the prognosis. The expression level of TC， TG， ACL， and anti-β 2-GP1 in poor prognosis group was higher than that in good prognosis group （P < 0.05）. TC， TG， ACL， and anti-β 2-GP1 was positively correlated with the poor prognosis of patients with atherosclerosis （P < 0.05）. ROC curve showed that the predictive value of six combined tests for the prognosis of patients with atherosclerosis was higher than that of single test of TC， TG， ACL， and anti-β2-GP1 （P < 0.05）. Conclusion The combined detection of TC， TG， ACL， and anti-β2-GP1 has high predictive value for the prognosis of patients with atherosclerosis.

Key words: atherosclerosis, indicators of glucose and lipid metabolism, antiphospholipid antibody, prognosis

CLC Number:

R541.4

Jia CUI,Mingming ZHANG,Na WANG,Wei GAO,Fei LI. Correlation analysis of glucose and lipid metabolism indicators combined with antiphospholipid antibodies on prognosis of patients with atherosclerosis[J]. The Journal of Practical Medicine, 2024, 40(3): 326-329.

Figures/Tables 6

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References 25

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组别	TC	TG
对照组（n = 48）	2.84 ± 0.32	1.47 ± 0.06
观察组（n = 128）	4.16 ± 0.88	2.59 ± 0.19
t值	10.130	40.030
P值	0.001	0.001

组别	ACL（U/mL）	抗β2-GP1（RU/mL）
对照组（n=48）	39.46 ± 9.67	17.34 ± 3.75
观察组（n=128）	46.28 ± 14.25	20.47 ± 5.93
t值	3.059	3.407
P值	0.003	0.001

组别	例数	TC（mmol/L）	TG（mmol/L）	ACL（U/mL）	抗β2-GP1（RU/mL）
预后良好组	72	3.91 ± 0.37	1.49 ± 0.08	39.52 ± 9.73	17.68 ± 3.80
预后不良组	56	4.11 ± 0.76	1.57 ± 0.10	45.69 ± 13.95	20.31 ± 5.73
t值		2.003	5.029	2.945	3.114
P值		0.041	0.001	0.004	0.002

指标	β	SE	Wald χ ²	OR	95%CI	P值
TC	2.324	0.628	13.695	10.216	8.960 ~ 11.472	0.001
TG	1.726	0.863	4.000	5.618	3.892 ~ 7.344	0.001
ACL	1.686	0.727	5.378	5.398	3.944 ~ 6.852	0.001
抗β2-GP1	2.418	0.835	8.386	11.223	9.553 ~ 12.893	0.001

指标	AUC（95%CI）	灵敏度（%）	特异度（%）	准确度（%）	P值
TC	0.660（0.570 ~ 0.750）	73.21（41/56）	86.11（62/72）	80.47（103/128）	0.002
TG	0.624（0.535 ~ 0.713）	78.57（44/56）	84.72（61/72）	82.03（105/128）	0.014
ACL	0.684（0.588 ~ 0.779）	83.93（47/56）	80.56（58/72）	82.03（105/128）	0.001
抗β2-GP1	0.710（0.621 ~ 0.800）	80.36（45/56）	79.17（57/72）	79.69（102/128）	0.001
4项联合	0.878（0.814 ~ 0.942）	96.43（54/56）	77.78（56/72）	85.94（110/128）	0.001

Correlation analysis of glucose and lipid metabolism indicators combined with antiphospholipid antibodies on prognosis of patients with atherosclerosis

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