Abstract:

Objective To investigate whether delirium associated with in ⁃ hospital mortality in patients with acute myocardial infarction. Methods This study used a retrospective cohort. The US Medical Information in Intensive Care database（MIMIC⁃IV）of patients with acute myocardial infarction was used to evaluate the indepen⁃ dent relationship between delirium and in⁃hospital mortality. To evaluate the independent relationship between delir⁃ ium and in ⁃ hospital mortality，inverse probability weighting was applied. Results Acute myocardial infarction patients with delirium had an in⁃hospital mortality rate that was 67% greater than those without delirium（inverse probability weighted result：HR = 1.67，95% CI：1.30 ~ 2.15，P < 0.001）. Sensitivity analyses utilizing Cox regression，adjusted propensity scores，propensity score matching，inverse probability weighting，and double robust analysis models revealed that the HR varied from 1.45 to 1.65. E value of 2.73 indicated that the results remain stable when considered uncontrolled confounding factors.）Conclusion Delirium was independently associ⁃ ated with increased in⁃hospital mortality in patients with acute myocardial infarction in the intensive care unit.

Key words:

delirium, intensive care unit, acute myocardial infarction, in?hospital mortality