Abstract:

Objective To investigatethe level of vitamin D in cord Blood with PROM and its relationshipwith early onset neonatal sepsis. Methods 80 cases of full⁃term neonates with PROM who were delivered in thematernity ward，the First Hospital of Hebei Medical University were selected from January 2018 to December 2018.They were divided into the early onset sepsis（EOS）group of 24 cases and the non EOS group of 56 cases. 30 healthyfull⁃term neonates born in the same period were selected as the control group. The cord blood of vitamin D levelswere measured with high performance liquid chromatography tandem mass spectrometry. The cord blood of PCTlevels were measured with micromagnetic grain of chemiluminescence immunoassay. Results The levels of cordblood 25（OH）D in non⁃EOS and EOS group were statistically significant compared with those in the control group（P < 0.05，P < 0.01）. The 25（OH）D levels of cord blood in the EOS group were statistically significant comparedwith the non⁃EOS group（P < 0.05）. Cord blood 25（OH）D was negatively correlated with PCT in EOS group（r = -0.511，P < 0.05）. The cord blood 25（OH）D deficiency rate was 91.7% in the EOS group ，73.2% in the nonEOS group ，40% in the control group，and statistically significant in the three groups（χ2 = 17.738，P < 0.01）. EOSgroup and non EOS group were statistically significant compared with the control group（all P < 0.01）. Conclusions The low level of cord blood 25（OH）D has a correlation with early onset neonatal sepsis.

Key words: infant, newborn, cord blood, 25（OH）D, premature rupture of membranes, early?onset sepsis