Abstract:

Neonatal hypoxic-ischemic encephalopathy refers to brain damage caused by perinatal asphyxia， which can cause death and permanent neurological impairment in severe cases. Therapeutic hypothermia reduces death or disability in term and near-term infants with moderate to severe hypoxic-ischaemic encephalopathy. The latest studies have further refined the key parameters of hypothermia， including the timing， depth of cooling， duration， subsequent rate of rewarming， and prevention of fever during delivery and resuscitation. The key to improving neurodevelopmental outcomes is early postnatal diagnosis and initiation of hypothermia. This article will review the research progress of mild therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy， and introduce commonly used hypothermia induction methods， clinical challenges and future development directions.

Key words: mild therapeutic hypothermia, hypoxic-ischemic encephalopathy, newborn, neuroprotective effect, neonatal examination