地奥司明对精索静脉高位结扎术后患者精液质量及性激素浓度的影响

doi:10.3969/j.issn.1006-5725.2024.03.019

Abstract

Abstract:

Objective To investigate the effect of diosmine on semen quality and sex hormone concentration in patients with spermatovenous ligation. Methods Clinical data were retrospectively collected from January 2019 to January 2022 on patients with varicocele admitted to Department of Urology， General Hospital of Southern Theater Command， divided into a control group and a study group based on whether they had a history of Diosmine use after surgery. Clinical data from both groups were matched using propensity score matching. Sperm quality and sex hormone tests were then compared before surgery， three months after surgery and six months after surgery. Results There were 73 in the control group and 73 in the study group. Both groups were balanced in terms of age， BMI， seminal fluid volume and testosterone （P > 0.05）. Sperm motility， forward motility and testosterone were all increased 3 and 6 months after surgery， and sperm malformations， sperm DNA fragment index， follicle stimulating hormone and luteinizing hormone were all reduced significantly （P < 0.05）. The results were also better than those in the control group for total sperm motility， forward motility， testosterone， sperm DNA fragment index， follicle stimulating hormone and luteinizing hormone （P < 0.05）. Conclusions Diosmine can help to restore semen quality and improve sex hormone concentration in patients with varicocele after Laparoscopic varicocelectomy.

Key words: varicocele, semen quality, laparoscopic varicocelectomy, diosmine

CLC Number:

R697⁺.24

Kaiqiang WANG,Zhi CAO,Wei WANG,Chenglin YANG,Yue YANG,Huifen ZHANG,Xaioming ZHANG. Effects of Diosmine on semen quality and sex hormone concentration in patients with spermatovenous ligation[J]. The Journal of Practical Medicine, 2024, 40(3): 389-393.

Figures/Tables 4

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References 26

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组别	例数	年龄（岁）	BMI（kg/m²）	曲张程度（例）		精液量（mL）	液化时间（min）	精子总数（对数）	精子总活力（%）	前向运动率（%）
组别	例数	年龄（岁）	BMI（kg/m²）	Ⅱ度	Ⅲ度	精液量（mL）	液化时间（min）	精子总数（对数）	精子总活力（%）	前向运动率（%）
匹配后对照组	73	26.56 ± 3.56	21.20 ± 1.14	30	43	4.02 ± 0.40	36.82 ± 11.88	8.19 ± 0.25	39.96 ± 5.68	26.40 ± 3.00
匹配后研究组	73	27.08 ± 3.39	20.98 ± 1.32	31	42	4.08 ± 0.42	35.03 ± 11.12	8.19 ± 0.23	40.60 ± 5.72	26.32 ± 3.24
t/χ²值		0.906	1.077	0.028		0.792	0.942	0.380	0.684	0.159
P值		0.367	0.283	0.867		0.429	0.348	0.705	0.495	0.874

组别	例数	精子畸形率（%）	精子DNA碎片指数（%）	精浆α-葡萄糖苷酶（U/L）	睾酮（nmol/L）	促黄体激素（IU/L）	促卵泡激素（IU/L）	垂体泌乳素（μg/L）	雌二醇（pmol/L）
匹配后对照组	73	94.82 ± 8.90	34.50 ± 5.43	35.30 ± 8.09	5.38 ± 0.89	11.45 ± 2.61	20.80 ± 3.31	10.68 ± 3.39	173.68 ± 49.95
匹配后研究组	73	96.60 ± 8.90	35.55 ± 6.24	36.27 ± 8.23	5.20 ± 0.95	11.86 ± 2.93	21.42 ± 3.61	10.06 ± 3.70	168.92 ± 51.57
t/χ²值		1.210	1.081	1.492	0.717	0.904	1.092	1.049	0.566
P值		0.228	0.281	0.137	0.475	0.368	0.277	0.296	0.572

组别	精液量（mL）			液化时间（min）
组别	术前	术后3个月	术后6个月	术前	术后3个月	术后6个月
匹配后对照组	4.02 ± 0.40	4.08 ± 0.28	4.08 ± 0.23	36.82 ± 11.88	35.75 ± 7.59	36.19 ± 6.72
匹配后研究组	4.07 ± 0.42	4.07 ± 0.27	4.04 ± 0.22	35.03 ± 11.12	38.36 ± 6.91^{a b}	37.92 ± 6.21
F值	0.003			0.952
P值	0.957			0.331
组别	精子总数（对数）			精子总活力（%）
组别	术前	术后3个月	术后6个月	术前	术后3个月	术后6个月
匹配后对照组	8.19 ± 0.25	8.20 ± 0.19^a	8.21 ± 0.19^a	39.96 ± 5.68	48.43 ± 7.12^a	55.48 ± 7.32^a
匹配后研究组	8.19 ± 0.23	8.20 ± 0.20^a	8.20 ± 0.19^a	40.60 ± 5.72	50.02 ± 7.40^a	58.38 ± 7.34^{a b}
F值	0.617			4.444
P值	0.433			0.037
组别	前向运动率（%）			精子畸形率（%）
组别	术前	术后3个月	术后6个月	术前	术后3个月	术后6个月
匹配后对照组	26.40 ± 3.00	29.34 ± 2.81^a	35.21 ± 4.23^a	94.82 ± 8.90	91.85 ± 8.55^a	81.62 ± 5.23^a
匹配后研究组	26.32 ± 3.24	31.67 ± 2.98^{a b}	37.37 ± 3.77^{a b}	96.60 ± 8.90	89.07 ± 7.16^{a b}	77.70 ± 3.71^{a b}
F值	14.402			3.970
P值	0.000			0.048
组别	精子DNA碎片指数（DFI）			精浆α-葡萄糖苷酶
组别	术前	术后3个月	术后6个月	术前	术后3个月	术后6个月
匹配后对照组	34.50 ± 5.43	30.81 ± 4.67^a	26.68 ± 6.31^a	35.30 ± 8.09	38.59 ± 5.90^a	40.59 ± 5.36^a
匹配后研究组	35.55 ± 6.24	28.92 ± 5.11^{a b}	20.64 ± 5.29^{a b}	36.27 ± 8.23	37.94 ± 5.20	39.67 ± 5.28^a
F值	11.057			0.081
P值	0.001			0.773

组别	T（nmol/L）			LH（IU/L）			FSH（IU/L）
组别	术前	术后3个月	术后6个月	术前	术后3个月	术后6个月	术前	术后3个月	术后6个月
匹配后对照组	5.36 ± 0.85	10.67 ± 0.76^a	15.88 ± 1.04^a	11.94 ± 2.99	11.90 ± 2.07^a	11.55 ± 2.30^a	21.58 ± 3.75	20.19 ± 2.59^a	19.18 ± 1.93^a
匹配后研究组	5.26 ± 0.93	11.27 ± 0.67^ab	16.24 ± 0.49^ab	11.36 ± 2.52	10.36 ± 1.71^ab	9.89 ± 1.93^ab	20.64 ± 3.10	19.54 ± 1.98^a	18.36 ± 1.52^ab
F值	7.051			16.11			4.988
P值	0.009			< 0.001			0.027

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Effects of Diosmine on semen quality and sex hormone concentration in patients with spermatovenous ligation

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