The Journal of Practical Medicine ›› 2023, Vol. 39 ›› Issue (3): 338-342.

• Drugs and Clinic Practice • Previous Articles     Next Articles

Role of seaweed biological glues in perforation healing and abdominal infection in patients with gastroduo⁃ denal perforation

PENG Huaidu，ZHANG Junshuo，ZHENG Chufa，CAI Chudong，ZHU Lingzhen，CAI Shu⁃ tian，FANG Xi，WU Junwei.   

  1. Department of General Surgery，Shantou Central Hospital，SUN Yat⁃sen University， Shantou 515031，China 

  • Online:2023-02-10 Published:2023-02-10

Abstract:

Objective To explore the role of seaweed biological glues（SBG）on perforation healing（PH） and abdominal infection（AI）in patients with gastroduodenal perforation（GDP）. Methods One hundred and six GDP patients were randomly divided into treatment group（n = 43）and control group（n = 63）. We detected the levels of white blood cells（WBC），C⁃reactive protein（CRP）and procalcitonin（PCT）before and 3 days after op⁃ eration and at the same time we observed the postoperative perforation healing situation，the abdominal drainage， anal exhaust time，ambulation time，wound healing，abdominal abscess，and time of hospital stay. Then we com⁃ pared the changes of the data between the two groups with statistical analysis，and explored the safety and efficacy of the seaweed biological glues（SBG）in gastroduodenal perforation（GDP）. Results The perforation healing rate was 100% in both groups. There was no significant difference in the preoperative inflammatory indicators WBC， CRP and PCT between the two groups. The WBC and CRP levels in the treatment group were significantly decreased on the third day after operation，while PCT was only slightly improved. The levels of WBC and CRP in the control group on the third day after surgery decreased slightly comparing with those before surgery and the level of PCT remained unchanged. After surgery，the levels of WBC and CRP in the treatment group were significantly lower than those in the control group（P < 0.05），while the level of PCT was insignificantly decreased in the treatment group comparing with the control group（P = 0.64）. There were no differences in postoperative abdominal drainage volume，exhaust time，ambulation time，incision infection rate and incidence of abdominal abscess between the two groups. However，postoperative abdominal drainage volume in the treatment group was marginally significantly lower than that in the control group（P = 0.069）. Conclusion Seaweed biological glues are safe in the treatmentof gastroduodenal perforation. It can not only promote perforation healing，but also effectively improve abdominal infection.

Key words:

seaweed biological glues, gastroduodenal perforation, perforation healing, abdominal infection