转录组学技术在急性白血病诊治中的应用研究进展

doi:10.3969/j.issn.1006-5725.2023.22.027

Abstract

Abstract:

Transcriptomics technology has been developed rapidly in recent years. It can perform transcriptome analysis of acute leukemia （AL）， and objectively and accurately detect abnormal genes and functional changes in AL cells， which is of great significance to further reveal the molecular mechanism of AL occurrence and development. RNA?sequencing （RNA?seq） technology is transcriptome sequencing technology. It not only can identify new oncogene fusions and characteristic molecular markers for more accurate classification and risk assessment of AL but also detect abnormal genes or cell subsets for adopting corresponding targeted therapy to improve the prognosis of AL patients. In addition， the combination of transcriptomics technology with other omics technologies can monitor the multi?omics changes of AL from different levels， and more comprehensively analyze the molecular mechanism of the occurrence and development of AL. With the continuous application of RNA?seq technology， it will provide new precise targets and clinical strategies for the treatment of AL.

Key words: transcriptomics, acute leukemia, RNA?sequencing technology, gene fusion

CLC Number:

R733.71

Xiao QIANG,Beibei GENG,Sixi LIU,Ting. XIA. Research progress on the application of transcriptomics technology in the diagnosis and treatment of acute leukemia[J]. The Journal of Practical Medicine, 2023, 39(22): 3010-3014.

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Research progress on the application of transcriptomics technology in the diagnosis and treatment of acute leukemia

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