Abstract:

Objective To study the clinical effects of personalized interventions on patients with type 2 diabetes mellitus with holistic integrative medicine（HIM）. Methods Thirty middle ⁃ aged and elderly patients with type 2 diabetes from communities in Guangzhou who volunteered to participate in the project were randomly selected. A multidisciplinary approach of health education and personalized intervention was used. The changes in patients' blood glucose biochemical indexes，blood pressure，anxiety，depression，physiological feelings and blood pressure levels before and after the intervention were compared. Results After 4~12 months of intervention，all glucose⁃lowering drugs were stopped in 13 patients；partially stopped in 15 patients，and 2 patients remained the same medication. The mean levels of biochemical indicators including fasting glucose（9.2 mmol/L and 6.9 mmol/L， respectively），2⁃hour postprandial glucose（12.3 mmol/L and 7.7 mmol/L，respectively）and glycated hemoglobin （7.7% and 6.4%，respectively）before and after the intervention were significantly decreased（P < 0.05）. After the intervention，36.7% of the patients reached the remission level of diabetes，20% reached the normal level of fasting glucose，2⁃hour postprandial glucose and glycated hemoglobin after stopping the hypoglycemic drugs for 3 months，and the glucose metabolism of the patients who did not reach the remission level also improved signif⁃ icantly（P < 0.05）. Seventy⁃five percent（9/12）of those with combined high blood pressure had normal blood pres⁃ sure after 3 months of discontinuation of antihypertensive drugs. Significant improvements in anxiety，depression and physiological perception indicators were also found（P < 0.05）. Conclusion Personalized intervention in the mode of HIM can significantly improve glucose metabolism，psychological status，physiological function and high blood pressure in middle⁃aged and elderly patients with type 2 diabetes. Remission or even reversal of diabetes can be expected within a short period of time in mild or moderate patients and significant improvement in glucose metabolism in severe patients is also found. It provide ideas for further optimization of diabetes prevention and control programs.

Key words:

holistic integrative medicine, type 2 diabetes, personalized intervention, middle?aged and elderly people