Abstract:

With the aging population increasing rapidly，neurodegenerative diseases have become the main cause of the high morbidity and disability of the elderly，causing a significant social and economic burden， and has received more and more attention. Because of their hidden onset，slow development，and complicated pathophysiological changes，no clear，specific，and reliable laboratory method for early diagnosis is available at present. Raman spectroscopy is an optical technology that detects the inelastic scattered light generated by the inter⁃ action between light and matter. It provides chemical fingerprint information of cells，tissues or biological fluids by detecting scattered light of molecules. More and more biomedical applications show Raman spectroscopy has the potential to detect new biomarkers. It can quickly and accurately screen the susceptibility and incidence of diseases， and has broad application prospects in the study of clinically relevant biological species，disease pathogenesis and diagnosis. The prospects of Raman spectroscopy for early diagnosis of neurodegenerative diseases are summarized in this article.

Key words:

Raman spectroscopy, Alzheimer′s disease, Parkinson′s disease, multiple Sclerosis