Abstract:

Objective To explore the expression of Toll⁃like receptor（TLR），D⁃dimer（D⁃D）and secreted immunoglobulin A（sIgA）/albumin（ALB）in patients with viral repeated respiratory infections（RRTIs），and ana⁃ lyze the relationship with severity of disease and prognosis. Methods A total of 75 patients with viral RRTIs were selected as the test group，and they were divided into 3 groups（mild group，n = 25；moderate group，n = 30 and severe group，n = 20）according to the severity of the disease. Another 30 healthy people were selected as the control group. The peripheral blood TLR2，TLR9 expression levels，plasma D ⁃D levels，sIgA/ALB expression in saliva were compared between the two groups. The patients were further divided into the good prognosis group and poor prognosis group ，the expression of the above indicators in the two groups were compared. Results The expression of TLR2，TLR9 in the peripheral blood and plasma D⁃D levels of the test group were significantly higher than those of the control group，and the sIgA/ALB expression level in saliva was significantly lower than that of the control group（P < 0.001）. The expression of TLR2，TLR9 in the peripheral blood and plasma D⁃D levels showed a gradual increase trend，the sIgA/ALB expression level in saliva showed a gradual decrease trend in the mild group，moderate group and severe group（P < 0.001）. The expression of TLR2，TLR9 in the peripheral blood and plasma D⁃D levels of the good prognosis group were significantly lower than those in the poor prognosis group，and the sIgA/ALB expression level in saliva was significantly higher than that in the poor prognosis group（P < 0.01）. Conclusions Patients with viral RRTIs have elevated plasma D⁃D levels and decreased mucosal immune function， the clinical severity and prognosis of patients could be predicted based on the expression of the above indicators.

Key words:

repeated respiratory infections, toll ?like receptor, D ?dimer, secreted immunoglobulin A, albumin