Abstract:

Objective To investigate the efficacy and safety of erythropoietin（EPO）combined with mild hypothermia in the treatment of moderate to severe neonatal hypoxic⁃ischemic encephalopathy（HIE）. Methods A randomized controlled study was conducted on 92 children with moderate to severe HIE who met the mild hypothermia criteria from March 2017 to June 2019 in our hospital，and they were grouped according to the random number table method，46 cases each. The experimental group was treated with mild hypothermia for 72 hours combined with EPO intravenous infusion（once every other day for 14 days），and the control group was given mild hypother⁃ mia for 72 hours and normal saline at the same dose and same method as EPO. Statistics compared the safety and routine biochemical indicators of the two groups during treatment，and compared the prognosis of the two groups， such as the efficacy，newborn behavior scale（NBNA），intelligent development（CDCC）score，and the incidence of sequelae. Results （1）the NBNA scores of 7 days，14 days，and 28 days after birth in the experimental group showed an increasing trend，and were all greater than those in the control group（P < 0.05）；the MDI and PDI scores of the 3⁃month⁃old，6⁃month⁃old and 12⁃month⁃old in the experimental group were larger than those in the control group（P < 0.05）；the incidence of sequelae in the experimental group was 8.70% compared with 13.04% in the control group，the difference was not statistically significant（P > 0.05）；（2）Conventional biochemical indicators：at the end of mild hypothermia treatment，after the end of EPO treatment，the two groups of Hb，RBC， HcT，PLT，alanine aminotransferase，myocardial enzymes，creatinine，CR were compared，the difference was not statistically significant（P > 0.05）；（3）Safety during treatment：there were no serious adverse events，treatment abandonment events，and death events during treatment between the two groups. There was no statistically signifi⁃ cant difference in the incidence of general adverse events between the two groups（P > 0.05）. Conclusion EPO combined with mild hypothermia in the treatment of moderate to severe HIE can further reduce early stress injury reduce intelligence and nerve injury of children，improve prognosis，and do not increase the risk of adverse events during treatment.

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