Abstract:

Objective To explore the incidence of pain flare following radiotherapy for painful bone metas⁃ tases and evaluate the clinical value of dynamic adjustment in dose of oxycodone hydrochloride sustained ⁃ release tablets during peri⁃radiotherapeutic period in treatment of metastasis bone pain in lung cancer. Methods Clinical data of 43 lung cancer patients with metastatic bone pain in our hospital from December 2018 to September 2021 were retrospectively analyzed. Pain score，the changes of pain degrees，and corresponding dose change of oxycodone hydrochloride sustained⁃release tablets during peri⁃radiotherapeutic period were collected to analyze the feasibility and effect of dynamic adjustment of oxycodone hydrochloride sustained⁃release tablets. Results The total analge⁃ sic effective rate of combined treatment was 76.7%（33/43），and the rate of complete relief of cancer pain was 23.3%（10/43）. The incidence of single occurrence of pain flare was 20.9%，and that of two times 9.3%（4/43） during peri⁃radiotherapeutic period. The incidence rate of gradual reduction of oxycodone hydrochloride sustained⁃ release tablets dose during peri⁃radiotherapeutic period was 86.04%（37/43），and that of gradual reduction of oxy⁃ codone hydrochloride sustained ⁃ release tablets dose 74.41%（32/43）within 1 month after radiotherapy. Dynamic adjustment in dose of tablets was required during the period. Conclusion Radiotherapy combined with opioids is a well ⁃ established and effective treatment alternative for symptomatic bone metastases. Pain flare is a common event，occurring in 20.9% of the patients receiving radiotherapy for symptomatic bone metastases. Dynamic adjust⁃ ment in dose of oxycodone hydrochloride sustained ⁃ release tablets could improve the efficacy and avoid opioid abuse.

Key words:

bone metastases , cancer pain , radiotherapy , oxycodone hydrochloride sustained? release tablets, dynamic adjustment