Abstract:

Objective To investigate the predictive value of D⁃dimer in pancreatic thrombosis after simul⁃ taneous pancreas⁃kidney transplantation. Methods From September 2020 to August 2021，a total of 54 patients underwent pancreas⁃kidney transplantation at the organ transplantation Center of our hospital were selected to compare the changes of D⁃dimer levels 1 day before surgery and 1，3，and 7 days after surgery with and without pancreatic thrombosis. The D⁃dimer level of transplanted pancreas with and without thrombosis was compared. ROC curve was drawn to analyze the diagnostic efficacy of D⁃dimer level in pancreatic graft thrombosis after combined pancreation⁃ kidney transplantation. Results There was no statistically significant difference in D ⁃dimer level 1 day before surgery between the group with and without pancreatic thrombosis（P > 0.05），and there were statistically significant differences in d⁃dimer levels 1d before surgery and 1d，3d and 7d after surgery（P < 0.05），there was no signifi⁃ cant difference in d⁃dimer level between groups 1 day before surgery，1 day after surgery，3 days after surgery and 7 days after surgery（P > 0.05）. There was statistically significant difference in the D⁃dimer level between the transplanted pancreas with thrombosis and without thrombosis（P < 0.05）. According to ROC curve，the optimal critical value of D⁃dimer for predicting pancreatic arteriovenous thrombosis was 3.305 mg/L，AUC was 0.828，sen⁃ sitivity was 88.9%，specificity was 77.8%，and Yoden index was 66.7%. Conclusion The level of D⁃dimer after pancreas⁃kidney transplantation is significantly higher than that before surgery，and the level of D⁃dimer in plasma is higher in the occurrence of pancreatic graft thrombosis. Therefore，3.305 mg/L D⁃dimer can be used as“risk value” for screening pancreatic graft thrombosis after simultaneous pancreas⁃kidney transplantation.

Key words:

D?dimer, simultaneous pancreas?kidney transplantation, pancreatic, thrombosis