Abstract:

Objective To observe the effect of sacubitril valsartan on ventricular remodeling in rabbits with chronic heart failure and explore its underlying mechanisms. Methods Rabbit models of chronic heart failure were established in the heart failure group and sacubitril valsartan group. The sacubitril valsartan group was given sacubitril valsartan（10 mg/kg）intragastric administration；the sham operation group and the heart failure group the equivalent amount of normal saline. Echocardiography and N⁃terminal pro⁃brain natriuretic peptide（NT⁃proBNP） in serum were detected，and western blot was performed to evaluate the expression level of signaling pathway related proteins，as well as the protein expression level of α⁃ SMA，ColⅠ，ColⅢ，MMP2，MMP9，TIMP1，TGF ⁃β， Smad2，Smad3，Smad6 and Smad7. Results Compared with the heart failure group，the protein level of α⁃SMA， ColⅠ，ColⅢ，MMP2，MMP9，TGF⁃β，Smad2 and Smad3 in the sacubitril valsartan group decreased，while the protein expression level of Smad6 and Smad7 increased. Conclusion Sacubitril valsartan can affect collagen fiber deposition and degradation，reduce myocardial fibrosis and improve myocardial remodeling by regulating the TGFβ/ Smad signaling pathway.

Key words:

sacubitril valsartan, chronic heart failure, ventricular remodeling