Abstract:

Objective To investigate the diagnostic value of ultrasonography，mammography and their combination in high⁃grade and middle⁃low⁃grade ductal carcinoma in situ（DCIS）. Methods A total of 161 patients with 196 lesions who underwent ultrasound and mammography examination and confirmed by surgical pathology in our hospital between January 2015 and December 2020 were included. Taking pathological diagnosis as the gold standard，196 lesions were divided into high ⁃grade DCIS group（n = 80）and middle ⁃low ⁃grade DCIS group （n = 116）. The sonographic and mammographic features were analyzed and compared between the two groups. The area under curve（AUC）of the receiver operating characteristic（ROC）was used to analyze the diagnostic values of ultrasound and/or mammography for the DCIS. Results The percentage of microcalcification of sonography in the high⁃grade DCIS group was significantly higher than that in the middle⁃low⁃grade DCIS group（P < 0.01）. The pro⁃ portion of mass of sonography in the high ⁃grade DCIS group was significantly lower than that in the middle ⁃low ⁃ grade DCIS group（P < 0.01）. The proportion of microcalcification of mammography in the high⁃grade DCIS group was significantly higher than that in the middle⁃low⁃grade DCIS group（P = 0.026）. The AUC of ultrasound and/or mammography for DCIS diagnosis were 0.783，0.895，and 0.957，respectively. Conclusion The ultrasonographic and mammographic features of microcalcification are correlated with high⁃grade DCIS and ultrasonographic features of mass are correlated with middle⁃low⁃grade DCIS. The combination of ultrasound and mammography can help to diag⁃ nostic both high⁃grade and middle⁃low⁃grade DCIS.

Key words:

ductal carcinoma in situ, high grade, middle?low grade, ultrasonography, mammography