Abstract:

Objective To explore the clinical features and outcomes of diabetic patients complicate with severe and critical COVID ⁃19. Methods The clinical data of severe and critical COVID ⁃19 patients were retro⁃ spectively analyzed，including 10 cases in the diabetes mellitus（DM）group and 35 cases in the non⁃DM group. The differences in clinical characteristics，treatment effects，and prognosis between the two groups were observed. Results The DM group had higher fever scores，fatigue scores，and breathlessness scores，CRP，PCT，SOFA score，antibiotic application rate，and mechanically assisted ventilation rate than those of the non⁃DM groups（P < 0.05），and LYM and PaO2/FiO2 were less than those of the non⁃DM group（P < 0.05）；the range of lung CT lesions was larger than that of the non⁃DM group（P < 0.05）. After treatment，time to change to normal type，fever time，clinical symptom relief time，hospitalization day in the DM group were longer than those of the non ⁃ DM group（P < 0.05）. No difference between was found between the two groups in nucleic acid negative time，nucleic acid re⁃positive rate，PaO2/FiO2，LMY，CRP，PCT，mortality rate at the time of discharge（P > 0.05）. Conclusion The conditions of diabetic patients were aggravated after infected with COVID⁃19 and more susceptible to bacterial infection during hospitalization. However，the prognosis could be improved and the mortality rate could be reduced by actively and effectively controlling blood sugar.

Key words:

COVID?19, diabetes mellitus, clinical characteristics, disease outcome