Abstract:

Objective To explore the effect of feeding at different times on postoperative curative effect， gastrointestinal function recovery and humoral immune indexes in patients with acute pancreatitis（AP）. Methods A retrospective analysis on the clinical data of 100 AP patients who were treated in our hospital from January 2010 to January 2020 was done. The patients were divided into three groups according to the postoperative feeding times： group A feeding within 24 hours，group B within 24 to 48 h，group C within 48 ~ 72 h. The three groups were compared in terms of the surgical indicators，curative effect，nutritional status，gastrointestinal function recovery， immune function and complication rate. Results The total effective rate of group A was insignificantly higher than group B（91.2% vs. 85.1%，P > 0.05）and higher than group C（91.2% vs. 82.1%，P > 0.05）. There was no significant difference in operation time，intraoperative blood loss and postoperative incision recovery among the three groups of patients（P > 0.05）. The time of conscious bowel movement，the time of first exhaust，and the time of defecation of group A was significantly than group B and group C（P < 0.05），and appetite in group A was significantly better than group B and group C（P < 0.05）. The levels of albumin and prealbumin in the three groups all increased significantly after surgery（P < 0.05），and among the groups，the level in group A was higher than in both group B and group C（P < 0.05）. The immune indexes of all the three groups decreased first and then increased（P < 0.05）， and immune indexes in group A were significantly higher than those in group B and group C（P < 0.05）. Suture removal time，total length of hospital stay，and total hospitalization costs in group A were significantly lower than group B and group C，and the complication rate of group A was significantly lower than group B（2.9% vs. 3.7%， P < 0.01）and group C（2.9% vs. 20.5%，P < 0.01）. Conclusion Different feeding times after surgery significantly affect the recovery of gastrointestinal function of AP patients Eating within 24 hours after surgery is safe and effective，which can promote the recovery of gastrointestinal function and improve nutritional status and immune function，thereby reducing the occurrence of complications，shortening the length of hospitalization，and reducing the cost of treatment，it is worthy of clinical promotion.

Key words:

acute pancreatitis, postoperative efficacy, gastrointestinal recovery, humoral immunity