Abstract:

Objective To explore the safety and effectiveness of Cook cervical ripening balloon（CCRB） and Simpubexant（dinoprostone）in inducing labor in pregnant women with hypertension in the third trimester. Methods A retrospective analysis was conducted to research into the data of full⁃term pregnant women with hypertension during pregnancy who were admitted to Anhui Maternity and Child Health Hospital from September 2018 to September 2020 with indications of labor induction and with a cervical Bishop score of < 6 points 104 cases were enrolled in the CCRB group and another 64 cases in the Simpubesheng group. The effects of promoted cervical ripening，the effect of labor induction，the fluctuation of blood pressure during labor induction，and the adverse maternal and infant complications of the two methods were compared. Results Simpubesheng was more effective in promoting cervical ripening than CCRB. The Bishop score of the cervix before the induction of labor in the Simpbe⁃ son group was significantly lower than that of the CCRB group（P < 0.05），but there was no significant difference between the two groups in the Bishop score of the cervix and the total effective rate of cervical ripening after induction of labor（P > 0.05）. T The rate of vaginal delivery within 12 hours of intervention was significantly higher than that in the CCRB group（P < 0.05）. The maximum blood pressure fluctuation in the Simpubeson group was significantly higher than that in the CCRB group（P < 0.05），but the two groups had adverse delivery complications and neonatal asphyxia. There was no statistical difference in incidence（P > 0.05）. Compared with CCRB，Simpubexen was more likely to cause side effects of excessive or frequent uterine contractions（P < 0.05）. Conclusion For pregnant women with hypertension during full⁃term pregnancy，Simpubexen and CCRB both is safe and effective in labor induction. When the cervical Bishop score is low，Simpubexen is more effective than CCRB in promoting cervical ripening，but it is easier. It can cause excessive uterine stimulation and large blood pressure fluctuations，so it must be used under close supervision.

Key words:

COOK cervical ripening balloon, simpubesheng, gestational hypertension, cervical ripening effect