Abstract:

Objective To explore the safety，feasibility and clinical value of No.253 lymph node dissection in indocyanine green（ICG）fluorescence⁃guided laparoscopic colorectal cancer surgery. Methods Clinical data of 145 patients with colorectal cancer in our department from Jun. 2019 to Jan. 2021 were retrospectively analyzed. Of the total，68 patients（ICG group）received submucosal injection of ICG via colonoscopy 1 to 3 days before surgery，followed by fluorescence imaging laparoscopic radical colorectal cancer surgery and 77 patients（control group）underwent routine laparoscopic radical resection of colorectal cancer at the same time. Whether ICG fluores⁃ cence navigation had advantages in No.253 lymph node dissection，and whether there were differences between the two groups in terms of operation time，estimated blood loss，postoperative recovery and short ⁃term complications were analyzed. Results The comparison of lymph node development and dissection between the two groups showed that there were 68 cases of successful lymph node fluorescence development in ICG group，with success development rate of 100%；60 cases in the control group，with a success rate of 88.2% in. The total number of lymph nodes detected in ICG group，the total number of positive lymph nodes and the total number of No.253 lymph nodes were significantly higher than those in the control group（P < 0.05）. The number of positiveNo.253 lymph nodes detected in ICG group had no statistical difference when compared with that in the control group（P > 0.05）. There was no significant difference between ICG group and the control group in terms of operation time，estimated blood loss，time of first ambulation after operation，time of first anal exhaust after operation，time of first liquid food intake after operation，postoperative hospital stay and short ⁃ term complications （P > 0.05）. Conclusion No.253 lymph node dissection in ICG fluorescence ⁃guided colorectal cancer surgery is safe and feasible. It has certain clinical application value. 

Key words:

colorectal cancer, fluorescence imaging, indocyanine green, lymphadenectomy