Abstract:

Objective To observe the thickness changes of ganglion cell complex in macular area of patients with diabetes，and to analyze its significance in the diagnosis of early diabetic retinopathy. Methods Eighty ⁃three patients（83 eyes）with diabetes were retrospectively analyzed，among whom 50 patients（50 eyes） without diabetic retinopathy（NDR）were assigned to NDR group，and the other 33 cases（33 eyes）with mild to moderate non⁃proliferative diabetic retinopathy（NPDR）were assigned to NPDR group. A total of 50 healthy people （50 eyes）were selected as the control group，and the thickness of GCC was detected by optical coherence tomogra⁃ phy（OCT），and the data were analyzed. Results Compared with the control group，the thickness of GCC of S3， N3，S6 and N6 sectors in NDR group were thinner（t = 0.049，0.044，0.040 and 0.049，P < 0.05），while those of S3，N3，S6，N6 and I6 sectors in NPDR group were thinner（t = 0.015，0.016，0.043，0.037，0.042，P < 0.05）， and the difference was statistically significant（P < 0.05）. Conclusion The thickness of GCC in patients with NDR and NPDR were significantly thinner than those of the healthy people. Early retinopathy in diabetic patients could be found through OCT detection.

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