Abstract:

Objective To investigate the risk factors of acute kidney injury in patients with septic shock caused by intra⁃abdominal infection. Methods 129 patients were enrolled and then 56 cases were divided into in AKI group and 73 cases in non⁃AKI group. The clinical data of the two groups were compared by univariate analy⁃ sis. Multiple logistic regression analysis was used to analyze the risk factors of Septic acute kidney injury in ICU patients. Using ROC curve to evaluate the ability of APTT and PCT in diagnosing AKI. Results Compared with the non⁃AKI group，PCT，APTT，serum albumin（Alb）et.al were statistically significant in AKI group（all P < 0.05）. APTT，PCT were independent risk factors for S⁃AKI（P < 0.01），and Alb was known as an independent protective factor for Septic acute kidney injury（P < 0.05）；The area under the curve（AUC）of APTT and PCT was greater than 0.8，the sensitivity and specificity of APTT and PCT were 75.0% ，85.2% ，73.4% ，74.1% respectively. Conclusion APTT and PCT level on admission to the ICU are significantly associated with acute kidney injury in patients with septic shock caused by intra⁃abdominal infection，and Alb level is known as an independent protec⁃ tive factor；APTT and PCT have certain diagnostic efficacy in evaluating Septic acute kidney injury.

Key words:

activated partial thromboplastin time, procalcitonin, septic shock, serum albumin, acute kidney injury, intra?abdominal infection