Abstract:

Objective To explore an accurate，economical and efficient intervention method for thalasse⁃ mia. Methods Blood samples were collected from 20，525 newlyweds for routine blood examination. In the study group，the people with positive result of screening for mean corpuscle volume received hemoglobin electrophoresis. After electrophoresis，some people were selected for α thalassemia gene detection，and all couples at risk of thalas⁃ semia were diagnosed. In the control group，hemoglobin electrophoresis was performed and 6 screening parameters were set to guide the couples with positive screening to take blood again for α and β gene detection，and all couples at risk of thalassemia were diagnosed. The couples at risk in both groups abandoned the affected fetus through prenatal diagnosis. Results 392 couples at risk were detected in 10，235 couples in the study group，the detection rate was 3.83%，and the average cost for each couples was 4，246 yuan. 392 couples was followed up；25 thalassemia fetuses were terminated within one year，with an average cost of 77，090 yuan per case. 207 couples at risk were detected in 10，290 couples in the control group，the detection rate was 2.01%，and the average cost for each pairs was 11，279 yuan；4，433 couples were followed up；7 thalassemia fetuses were terminated within one year，with an average cost of 34，5436 yuan per case. There were significant differences between the two groups in the detection rate of risk couples，the cost of intervention for each thalassemia fetus，and the number of people to be followed up. Conclusions Use of manpower and testing cost weremarkedly less in the study group than in the control group，but the rate of successful intervention of thalassemia fetuses was significantly higher. Reasonable selection of screening methods and process can significantly improve the efficiency.

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