Abstract:

Objective To investigate the correlation between gait speed and mortality in elderly inpatients with hypertension. Methods From June 2015 to December 2017，we conducted to examine elderly patients aged ≥ 65 years at our hospital. Patients’basic information，biochemical indicators，comorbidities and polypharmacy were recorded at admission. We used 6m walking test to measure gait speed. Activities of daily living was assessed by Katz⁃ADL，cognitive function by mini⁃mental state Examination（MMSE）and nutrition level by micronutrient assess⁃ ment method summary（MNA⁃SF）. After discharge，all⁃cause mortality was followed up for more than 2 year and recorded. We analyzed the correlation between gait speed and mortality. Results A total of 515 patients［（84.1 ± 5.9）years，58.1% men］were enrolled. During a median follow ⁃up of 3.3 years（IQR 2.7，3.9），106 participants （20.6%）died. Spearman correlation analysis revealed that gait speed was negatively correlated with age，CCI and polypharmacy，and positively correlated with 24hDBP levels，Katz⁃ADL，MMSE，and MNA⁃SF scores（P < 0.05）. Gait speed was divided into tertile groups. The Kaplan Meier curve showed that mortality increased with the decrease of gait speed（log rank：P < 0.001）. Cox regression analysis with adjustment for potential confounding variables showed that compared with the highest group，the lowest group had a higher risk of mortality（HR = 2.325，95%CI： 1.113 ~ 4.855，P = 0.025）. Conclusions In elderly in⁃patients with hypertension，low gait speed is associated with 

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