Abstract:

Objective To analyze the relationship between myocardial damage and death in critical coronavirus disease 2019（COVID⁃19）. Methods A total of 113 critical COVID⁃19 patients were selected in our hospital from February 1，2020 to March 25，2020. Univariate analyses were used to compare two groups（death group and survival group）. Then，the receiver operating characteristic curve（ROC）was performed to assess the predictive value of myocardial injury markers for death. Results A total of 113 critical patients with COVID ⁃19 were recruited，including 68 male and 45 female. The mean age was（67.25 ± 14.06）years，ranging from 29 to 95 years. In univariate analysis，the following factors had significant differences between death group and survival group（P < 0.05）：Age > 70 years，hypertension，coronary heart disease and body temperature > 39℃. Multivariate analysis showed hypersensitive troponin I（Hs⁃TnI）greater than 0.04 μg/L（HR = 2.10，95% CI：1.13 ~ 3.91）， myoglobin（MYO）greater than 100 μg/L（HR = 2.14，95% CI：1.15 ~ 3.97），and white blood cell count（WBC） greater than 9.5 × 109 /L（HR = 2.18，95% CI：1.20 ~ 3.98）were the independent predictors of mortality in COVID⁃19. ROC curve showed myocardial injury markers Hs⁃TnI，CK⁃MB，and MYO had excellent predictive significance for the risk of death in critical COVID ⁃ 19（P < 0.05）. Conclusions Critical COVID ⁃ 19 patients with myocardial damage had a high fatality. The myocardial injury markers Hs⁃TnI，CK⁃MB，and MYO had excellent predictive significance for the risk of death in critical COVID⁃19. It is of important significance in early discovering predictive information，assessing risks of death，

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