Abstract:

Objective The research aimed to investigate the effects of goal⁃directed fluid therapy on hemo⁃dynamics and S100β protein in patients undergoing meningioma resection. Methods Forty⁃eight patients undergo⁃ing meningioma resection with supine position were randomly divided into 2 groups：routine fluid therapy group（group C）and GDFT group（group G）. The strategy in group G is to maintain stroke volume variation（SVV）<13%. Fluid therapy was based on the normal artery pressure ，hemoglobin and hematocrit. The hemodynamicindexes were recorded at all time intervals. S100 β protein and rehabilitation indicators in two groups perioperative.Results Compared with group C，the urine volume，amount of colloids，MAP and CI were significantly increased⁃while the amount of crystals，the total fluid intake and output，the concentration of S100 β protein，the length ofstay in the ICU and hospital were significantly decreased in group G（P < 0.05）. Conclusion During meningiomaresection，GDFT guided with SVV not only maintain the effective circulating blood volume and systemic perfusionbut also decrease the concentration S100 β protein，improve clinical outcomes.

Key words: goal?directed fluid therapy , stroke volume variation , meningioma resection , S100
β protein, cognitive function