植物来源细胞外囊泡在类风湿关节炎治疗中的研究进展与转化前景

doi:10.3969/j.issn.1006-5725.2026.12.012

Abstract

Abstract:

Rheumatoid arthritis （RA） is a chronic autoimmune disease characterized by persistent synovitis， progressive joint destruction， and multisystem involvement. Although current pharmacotherapies have significantly improved the clinical outcomes of RA， challenges remain， including adverse effects， high economic burden， and inadequate treatment response in some patients. Plant-derived extracellular vesicles （PDEVs）， as a novel class of natural nanocarriers， possess the dual attributes of endogenous bioactivity and drug delivery vehicles， offering advantages such as broad availability， convenient preparation， low immunogenicity， and high biosafety. In recent years， research on PDEVs in the treatment of RA has been increasing， and their application value in immunomodulation， anti-inflammatory intervention， and targeted delivery has garnered considerable attention， providing innovative strategies for RA therapy. This review systematically summarizes the structural characteristics， isolation， purification， and characterization methods of PDEVs， with a focus on their research progress and underlying mechanisms in RA treatment， aiming to provide a reference for related basic research and clinical translation.

Key words: rheumatoid arthritis, plant-derived extracellular vesicles, nanodrug delivery system, immunomodulation, drug delivery

CLC Number:

R593.22

Rui WANG,Shiyu JI,Feng LUO,Qiuyi WANG,Xueming YAO. Research progress and translational prospects of plant-derived extracellular vesicles in the treatment of rheumatoid arthritis[J]. The Journal of Practical Medicine, 2026, 42(12): 2179-2184.

Figures/Tables 1

References 34

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PDEVs	作用	参考文献
pueraria-derived exosome-like nanovesicles	抑制PEA-BTK-NETs-信号轴	［23］
extracellular vesicles treated with Duhuo Jisheng Decoction	抑制滑膜成纤维细胞的增殖、迁移与侵袭，诱导其凋亡	［25］
ginseng-derived nanoparticles	抑制KRAS-MAPK信号通路	［27］
folic acid-modified ginger-derived extracellular vesicles	激活PI3K-AKT通路，调控巨噬细胞极化	［8］
peucedanum japonicum-derived exosome-like nanovesicles	抑制NF-κB与JAK-STAT信号通路	［28］

Research progress and translational prospects of plant-derived extracellular vesicles in the treatment of rheumatoid arthritis

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